氧化应激与阿尔采末病

被引：7

作者：

卓烨烨 ^{[1
]}

张汉霆 ^{[1
,2
]}

徐江平 ^{[1
]}

机构：

[1] 南方医科大学药学院药理学系

[2] Depts of Behavioral Medicine&Psychiatry and Physiology & Pharmacology,West Virginia University Health Sciences Center

来源：

中国药理学通报 | 2010年 / 26卷 / 04期

基金：

广东省自然科学基金;

关键词：

阿尔采末病; 氧化应激; 发病机制; 神经元; 自由基; 抗氧化剂; 磷酸二酯酶抑制剂;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

阿尔采末病(Alzheimer’s disease,AD)是一种以进行性认知功能障碍和记忆力损害为主的中枢神经系统退行性疾病。对AD的发病机制存在多种假说,其中氧化应激假说目前越来越受到重视。该文从自由基来源、AD病理特征与氧化应激的关系、相关的动物和临床相关研究、常用抗氧化剂和磷酸二酯酶抑制剂在抗氧化应激方面对AD的治疗作用等,对近年来国内外氧化应激与AD关系的研究进行简要综述。

引用

页码：435 / 437

页数：3

共 10 条

[1] 磷酸二酯酶抑制剂与学习记忆相关信号转导通路研究进展 [J].

王闯 ;

程玉芳 ;

张汉霆 ;

徐江平 .

中国药理学通报, 2009, (07) :844-847

[2]

Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor[J] . Rahul Deshmukh,Vivek Sharma,Sidharth Mehan,Nidhi Sharma,K.L. Bedi.European Journal of Pharmacology . 2009 (1)

[3] Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice [J].

Saxena, Gunjan ;

Singh, Sheelendra Pratap ;

Agrawal, Rahul ;

Nath, Chandishwar .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 581 (03) :283-289

[4] Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease [J].

Resende, Rosa ;

Moreira, Paula Isabel ;

Proenca, Teresa ;

Deshpande, Atul ;

Busciglio, Jorge ;

Pereira, Claudia ;

Oliveira, Catarina Resende .

FREE RADICAL BIOLOGY AND MEDICINE, 2008, 44 (12) :2051-2057

[5] Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators [J].

St-Pierre, Julie ;

Drori, Stavit ;

Uldry, Marc ;

Silvaggi, Jessica M. ;

Rhee, James ;

Jager, Sibylle ;

Handschin, Christoph ;

Zheng, Kangni ;

Lin, Jiandie ;

Yang, Wenli ;

Simon, David K. ;

Bachoo, Robert ;

Spiegelman, Bruce M. .

CELL, 2006, 127 (02) :397-408

[6]

Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils[J] . Takashi Kyoi,Kumiko Noda,Michiko Oka,Yojiro Ukai.Life Sciences . 2004 (1)

[7]

Oxidative stress signalling in Alzheimer’s disease[J] . Xiongwei Zhu,Arun K. Raina,Hyoung-gon Lee,Gemma Casadesus,Mark A. Smith,George Perry.Brain Research . 2004 (1)

[8]

4-Hydroxynonenal and neurodegenerative diseases[J] . Kamelija Zarkovic.Molecular Aspects of Medicine . 2003 (4)

[9] Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease [J].

Matsubara, E ;

Bryant-Thomas, T ;

Quinto, JP ;

Henry, TL ;

Poeggeler, B ;

Herbert, D ;

Cruz-Sanchez, F ;

Chyan, YJ ;

Smith, MA ;

Perry, G ;

Shoji, M ;

Abe, K ;

Leone, A ;

Grundke-Ikbal, I ;

Wilson, GL ;

Ghiso, J ;

Williams, C ;

Refolo, LM ;

Pappolla, MA .

JOURNAL OF NEUROCHEMISTRY, 2003, 85 (05) :1101-1108

[10] Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease [J].

Marcus, DL ;

Thomas, C ;

Rodriguez, C ;

Simberkoff, K ;

Tsai, JS ;

Strafaci, JA ;

Freedman, ML .

EXPERIMENTAL NEUROLOGY, 1998, 150 (01) :40-44

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