Toll样受体信号转导与原发性肝癌发生发展关系的研究进展

被引：9

作者：

徐恩君

刘亚婷

李涛

机构：

[1] 安徽医科大学第一附属医院检验科

来源：

免疫学杂志 | 2015年 / 31卷 / 08期

关键词：

Toll样受体; 信号通路; 病原相关分子模式; 肝癌;

D O I：

10.13431/j.cnki.immunol.j.20150154

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

肝细胞性肝癌(hepatocellular carcinoma,HCC)的死亡率位居世界恶性肿瘤的第2位,炎症是肝癌的主要原因。Toll样受体(Toll-like receptors,TLRs)为天然免疫的病原相关分子模式(pathogen associated molecular patterns,PAMPs)识别受体,TLRs不仅在免疫细胞中表达,在多种恶性肿瘤细胞及组织中均有表达,TLRs信号通路的激活可导致天然免疫系统产生炎症因子和趋化因子,最终激活获得性免疫系统。TLRs可能通过促进肿瘤细胞的增殖,协助肿瘤细胞的凋亡及免疫逃逸等机制参与原发性肝癌的发生发展。

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页码：727 / 732

页数：6

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