喹诺酮类药物残留检测方法

被引:21
作者
李雅丽
胥传来
机构
[1] 江南大学食品学院
关键词
喹诺酮; 残留; 分析方法;
D O I
暂无
中图分类号
TS207.53 [];
学科分类号
083201 ;
摘要
喹诺酮类抗生素是人工合成萘啶酸衍生物,通过抑制DNA旋转酶的活性杀死细菌的,因其有抗菌谱广、吸收好、血液浓度高、能迅速分解到各组织、半衰期长、能制成各种剂型等特点而得到迅速推广。但喹诺酮抗生素对人体有一定的副作用。目前该类药物已被广泛应用于家禽家畜的疾病防治中,因而肉类和蛋类中的喹诺酮药物残留量已引起人们的广泛关注。欧共体国家(EU)早在20世纪90年代就对肉类中喹诺酮类抗生素的最大残留量进行了限制。由此产生很多喹诺酮类抗生素多残留的分析方法。本文主要介绍了喹诺酮类药物的种类、应用、不良反应,以及各种残留分析方法,主要包括高效液相法(HPLC)以及与此相关的HPLC-UV、HPLC-FD、HPLC-DVD、LC-MS-MS,LC-ESI-MS-MS;另外还有荧光光谱法、毛细管电泳法和酶联免疫法等。
引用
收藏
页码:628 / 633
页数:6
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