表观遗传学在骨性关节炎研究中的进展

被引：5

作者：

应璞

翁文杰

蒋青

机构：

[1] 南京大学医学院附属鼓楼医院关节疾病诊治中心

来源：

中国矫形外科杂志 | 2012年 / 20卷 / 24期

基金：

国家杰出青年科学基金;

关键词：

表观遗传修饰; 骨性关节炎; DNA甲基化; 组蛋白修饰; miRNA;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

<正>骨性关节炎(osteoarthritis,OA)是一种最常见的以关节软骨退变为主要病理改变的年龄相关性退化疾病,可表现为不同程度的关节软骨丢失、骨质增生、软骨下骨改变和滑膜炎等。近年来越来越多的证据表明表观遗传修饰在OA发生发展中扮演着非常重要的作用。表观遗传学研究与DNA序列无关的基因表达调控,包括DNA甲基化、组蛋白修饰、miRNA、基因印记等。表观遗传调控可以作为研究

引用

页码：2264 / 2267

页数：4

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