山药硒多糖对CCl4诱导小鼠急性肝损伤的保护作用

被引：19

作者：

滕杨 ^{[1
]}

谷娜 ^{[2
]}

罗时旋 ^{[2
]}

李建慧 ^{[2
]}

郑晓凤 ^{[2
]}

侯丽然 ^{[2
]}

侯巍 ^{[1
]}

高金波 ^{[1
]}

机构：

[1] 黑龙江省教育厅生物药制剂重点实验室

[2] 佳木斯大学

来源：

食品工业科技 | 2015年 / 36卷 / 15期

关键词：

山药硒多糖; 四氯化碳; 肝损伤; 保护作用;

D O I：

10.13386/j.issn1002-0306.2015.15.068

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的:探究山药硒多糖对CCl4导致小鼠急性肝损伤的保护作用。方法:采用CCl4诱导小鼠肝损伤模型,测定山药硒多糖对小鼠血清中ALT、AST、ALP、ALB、γ-GT、TP,组织匀浆中MDA、GSH水平的影响,并结合病理学HE染色,研究其对小鼠急性肝损伤的保护作用。结果:山药硒多糖高剂量组与模型组相比可显著地降低血清中的ALT、AST、ALB和ALP(p<0.01)以及肝组织中的MDA和GSH(p<0.05)含量,与对照组相比无显著差异,中剂量治疗组血清和肝组织中各种指标与模型组相比有极显著差异(p<0.01),与对照组相比有显著性差异(p<0.05),中、高剂量治疗组均可不同程度地改善CCl4所致的病理组织损伤,且显著优于低剂量组与山药多糖治疗组。结论:山药硒多糖对CCl4所致的小鼠急性肝损伤具有保护作用,且随浓度增高保护作用加强。

引用

页码：362 / 364+369 +369

页数：4

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