天然产物中α-葡萄糖苷酶抑制剂的筛选研究进展

被引：31

作者：

屠洁

李前龙

机构：

[1] 江苏科技大学生物与环境工程学院

来源：

食品研究与开发 | 2010年 / 31卷 / 09期

关键词：

α-葡萄糖苷酶抑制剂; 天然产物; 筛选;

D O I：

暂无

中图分类号：

R284 [中药化学];

学科分类号：

100804 [中药化学];

摘要：

综述天然产物中α-葡萄糖苷酶抑制剂的理化性质及其筛选方法。目前用于α-葡萄糖苷酶抑制剂筛选的天然材料主要包括草药、海洋无脊椎动物、海藻以及一些药食两用的农产品。这些天然抑制剂的筛选主要以体外α-葡萄糖苷酶抑制活性为依据,分离纯化则主要经有机溶剂提取、分步萃取后,硅胶或大孔吸附树脂、凝胶过滤分离纯化,高效液相色谱、质谱、核磁共振等检测方法进行物质结构的鉴定。

引用

页码：206 / 210

页数：5

共 21 条

[1]

New Labdane diterpenes as intestinal α-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes [J].

Reddy, P. Prabhakar ;

Tiwari, Ashok K. ;

Rao, R. Ranga ;

Madhusudhana, K. ;

Rao, V. Rama Subba ;

Ali, Amtul Z. ;

Babu, K. Suresh ;

Rao, J. Madhusudana .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (09) :2562-2565

[2]

Composition and enzyme inhibitory properties of finger millet (Eleusine coracana L.) seed coat phenolics: Mode of inhibition of α-glucosidase and pancreatic amylase [J].

Shobana, S. ;

Sreerama, Y. N. ;

Malleshi, N. G. .

FOOD CHEMISTRY, 2009, 115 (04) :1268-1273

[3]

Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats [J].

Namaboot, Jarinyaporn ;

Pannangpetch, Patchareewan ;

Kukongviriyapan, Veerapol ;

Kukongviriyapan, Upa ;

Nakmareong, Saowanee ;

Itharat, Arunporn .

NUTRITION RESEARCH, 2009, 29 (08) :602-608

[4]

New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana [J].

Luo, Han-Guang ;

Ma, Li ;

Kong, Ling-Yi .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (06) :2912-2920

[5]

Potent α-glucosidase inhibitors purified from the red alga Grateloupia elliptica [J].

Kim, K. Y. ;

Nam, K. A. ;

Kurihara, H. ;

Kim, S. M. .

PHYTOCHEMISTRY, 2008, 69 (16) :2820-2825

[6]

α-Glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto–Kakizaki (GK) rats.[J].Jayantrao Shinde;Tony Taldone;Michael Barletta;Naveen Kunaparaju;Bo Hu;Sunil Kumar;Jessica Placido;S. William Zito.Carbohydrate Research.2008, 7

[7]

Effects of sources of carbon and nitrogen on production of α-glucosidase inhibitor by a newly isolated strain of Bacillus subtilis B2 [J].