迭鞘石斛中性多糖DDP1-1的体内免疫活性

被引：37

作者：

范益军 ^{[1
]}

淳泽 ^{[2
]}

罗傲雪 ^{[1
]}

罗傲霜 ^{[2
]}

何涛 ^{[2
]}

何兴金 ^{[3
]}

机构：

[1] 四川农业大学都江堰校区

[2] 中国科学院成都生物研究所

[3] 四川大学生命科学院

来源：

应用与环境生物学报 | 2010年 / 16卷 / 03期

关键词：

迭鞘石斛; 中性多糖; 体内免疫; 细胞因子;

D O I：

暂无

中图分类号：

R284 [中药化学]; R285 [中药药理学];

学科分类号：

100804 [中药化学]; 100806 [中药药理学];

摘要：

建立S180肉瘤模型,考察了迭鞘石斛中性多糖的体内免疫活性.以不同浓度的多糖作为药物组,环磷酰胺为阳性对照,生理盐水为阴性对照.给药14d后处死并解剖小鼠,眼眶取血,计算抑瘤率和免疫指数,检测血清中TNF-α、IL-2和IFN-γ含量.结果显示不同浓度的多糖表现出不同的免疫活性,其中多糖低浓度组(1.25mg/mL)有较高的肿瘤抑制率和免疫指数(P<0.01),并促进和调节IL-2、IFN-γ、TNF-α在机体内分泌(P<0.01),协调改善机体免疫系统功能,达到治疗肿瘤的目的.

引用

页码：376 / 379

页数：4

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