大豆肽钙对大鼠骨密度的影响

目的探讨大豆肽钙对大鼠钙表观吸收率及骨密度的影响。方法将雄性Wistar大鼠50只按体质量均衡原则随机分为5组:低钙对照组、碳酸钙对照组及大豆肽钙低、中、高剂量组,各组大鼠自由进食相应的专配饲料。实验第4周末,进行3d的钙代谢实验,计算各组的钙表观吸收率;大鼠喂养13周后处死,剥离左、右侧股骨。取右侧股骨测定骨钙含量,左侧股骨测定骨密度。结果 (1)钙代谢实验:碳酸钙对照组钙表观吸收率为69.9%,而中、高剂量大豆肽钙组分别为82.6%和77.4%,差异有统计学意义(F=31.371,P=0.000,0.001);(2)骨密度实验:与低钙对照组比较,大豆肽钙中、高剂量组大鼠体质量(F=3.150,P=0.010,0.002)、股骨质量(F=3.195,P=0.015,0.002)、骨钙含量(F=4.506,P=0.004,0.001)、股骨中点骨密度(F=6.185,P=0.006,0.000)及远心端骨密度(F=6.081,P=0.027,0.000)均增加明显,与碳酸钙对照组比较,除体质量指标(F=3.150,P=0.212)外,大豆肽钙高剂量组也呈现相同的结果(P值分别为0.046,0.024,0.013,0.001)。结论大豆肽钙可促进钙的吸收,增加大鼠骨密度。