Ⅰ型胶原蛋白的结构、功能及其应用研究的现状与前景

被引:51
作者
张达江
王亮
机构
[1] 中国科学院新疆分院理化技术研究所
关键词
胶原蛋白; 生物反应器; 转基因;
D O I
暂无
中图分类号
Q51 [蛋白质];
学科分类号
071010 ; 081704 ;
摘要
胶原蛋白是动物体中普遍存在的一种大分子蛋白,在哺乳动物中的含量是整个生物体自身总蛋白含量的1/4。胶原蛋白除了具有生物力学方面的作用以外,还具有诸如信号转导、生长因子与细胞因子的运输等功能;此外,在食品、化妆品、医药等行业中,胶原蛋白也具有很广泛的用途。随着对胶原蛋白需求的日益增加,原先从屠宰的动物体的皮革、骨骼中提取胶原的方式已经不能满足日益增长的胶原蛋白的需求,而且还可能有致病之虞,于是新的生产胶原蛋白的方法——利用生物反应器,尤其是乳腺生物反应器来生产胶原蛋白就为人们所瞩目。本文就Ⅰ型胶原蛋白的结构、功能,以及利用生物反应器研究开发Ⅰ型胶原蛋白的现状、前景进行了探讨。
引用
收藏
页码:265 / 269
页数:5
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共 61 条
[41]  
Intracellular interaction of collagen-specific stress protein H sp47with newly synthesized procollagen. Satoh M,H irayoshi K,Yokota S,et al. The Journal of Cell Biology . 1996
[42]  
Further hydroxylation of lysyl hydroxylase in vitro. K ivirikko K I,R yhanen L,Anttinen H,et al. Biochemistry . 1973
[43]  
Em bryonic lethality of m olecular chaperone H sp47knockout m ice is associated with defects in collagen biosynthesis. N agai N,H osokawa M,Itohara S,et al. The Journal of Cell Biology . 2000
[44]  
The bladder as a bioreactor:urothelium production and secretion of growth horm one into urine. K err DE,Liang F,Bondioli KR,et al. Nature Biotechnology . 1998
[45]  
M aking recom binant proteins in anim als-different system s,different applications. D yck M K,Lacroix D,Pothier F,et al. Trends in Biotechnology . 2003
[46]  
Oxidative protein folding in bacteria. Collet JF,Bardwell JC. M ol M icrobiol . 2002
[47]  
Transgenic production of a variant of hum an tissue-type plasm inogen activator in goat m ilk:generation of transgenic goats and analysis of expression. Ebert K M,Selgrath JP,Di Tullio P,et al. Bio Technology . 1991
[48]  
Rabbit b-casein prom oter directs secretion of hu-m an interleukin-2into the m ilk of transgenic rabbits. Buhler TA,Bruyere T,W ent D F,et al. Bio Technology . 1995
[49]  
Expression and characterization of biologically ac-tive hum an extracellular superoxide dism utase in m ilk of transgenic m ice. H ansson L,Edlund M,Edlund A,et al. Journal of Biological Chemistry . 1994
[50]  
Bovineαs1-casein gene sequences direct high level ex-pression of active hum an urokinase in m ouse m ilk. M eade H,Gates L,Lacy E,et al. Bio Technology . 1990