帕金森病病因及发病机制的研究进展

被引:10
作者
王赟
刘远新
李婕
张彪
机构
[1] 新疆医科大学
关键词
帕金森病; PD; GBA; 黑质; 中脑; 多巴胺能神经元; 线粒体功能障碍; 发病机制;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征];
学科分类号
1002 ;
摘要
<正>帕金森病(Parkinson disease,PD)又称为震颤麻痹,是一种常见的中老年渐进性中枢神经系统变性疾病,以锥体外系运动障碍为特征,主要表现为静止性震颤、肌肉僵直、运动弛缓、体位不稳、自主神经功能障碍、感觉障碍、情绪及精神改变、智力改变及睡眠障碍[1]。PD已经成为严重影响人类特别是老年人健康的重要疾病之一。PD病因和发病机制迄今未明,可能与老龄化、经常接触或暴露于杀虫剂与某些金属、
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页码:640 / 642+646 +646
页数:4
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