血流剪切力对支架内新生动脉粥样硬化形成的影响

被引：3

作者：

谢祖龙 ^{[1
]}

房炎 ^{[2
]}

王学懂 ^{[2
]}

田进伟 ^{[2
]}

杜华安 ^{[1
]}

于波 ^{[2
]}

机构：

[1] 重庆医科大学附属第二医院心血管内科

[2] 哈尔滨医科大学附属第二医院心血管内科

来源：

现代生物医学进展 | 2018年 / 18卷 / 08期

关键词：

支架内斑块; 血流剪切力; 光学相干断层成像; 超声;

D O I：

10.13241/j.cnki.pmb.2018.08.015

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

目的:探讨血流剪切力对支架内新生粥样硬化斑块形成的影响。方法:在6只新西兰白兔右髂动脉植入金属裸支架,术后高脂喂养8周。将支架按长度均等分为近中远3段,应用多普勒超声测量各支架段血管的血流速度和血管内径,根据Poiseuille定律计算出术后即刻及术后8周时各支架段的平均血流剪切力。应用光学相干断层成像技术(optical coherence tomography,OCT)检测术后8周支架内新生内膜的生长情况及特性。结果:成功建立支架内斑块动物模型。术后即刻近中远支架段的血流剪切力分别为4.25±0.92,2.49±1.07,1.67±0.49Pa(P<0.05);术后8周近中远支架段血流剪切力分别为20.40±6.07,11.09±1.74,7.97±0.26Pa(P<0.05),均较术后即刻明显升高(P<0.001);术后8周近中远支架段的内膜异质性发生率分别为86.67%,53.33%,41.12%(P<0.05);术后8周近中远支架段OCT检测的富含脂质斑块的发生率分别为53.3%,20%,0%(P<0.05)。结论:支架内新生粥样硬化斑块的发生可能与较高的血流剪切力相关。

引用

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页码：1479 / 1483+1568 +1568

页数：6

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