抗氧化剂茶多酚对微循环的影响及成因探讨

Objectives: To study the effects of tea polyphenols（TP） on bulbar conjunctiva microcirculation（BCM） and antioxidation in aircrew and find out the proper antioxidant for the health protection of aircrew. Methods: 40 healthy aircrew were divided into TP group（TP 600 mg/24 h, po） and control group（placebo） randomly. The effects of TP on microcirculation and antioxidation in aircrew were tested after 20 days. Results: The results showed that red blood cell（RBC） superoxide dismutase（SOD） activity and GSH Px（Whole blood glutathione peroxidase）/MDA（serum malondialdehyde） ratio in TP group were significantly higher than those in controls（ P < 0.01 ）, and serum MDA level was significantly decreased after TP administration（ P < 0.05 ）. The numbers capillaries and blood flow in microangium were significantly increased, RBC aggregation, ischemia area and A（arteriole）/V（venule） ratio were remarkably decreased in TP group（ P < 0.01 ~ 0.05 ）. The total integral value of microcirculation in TP group was significantly reduced in comparison with that in the control group. Conclusion: TP can significantly increase the antioxidative ability of aircrew, decrease the BCM disturbance and improve the microcirculatory function.