NLRP3炎症小体及其在消化系统疾病中的作用

被引：4

作者：

蔡燕 ^{[1
]}

祝荫 ^{[2
]}

机构：

[1] 南昌大学研究生院医学部

[2] 南昌大学第一附属医院消化内科

来源：

南昌大学学报(医学版) | 2018年 / 58卷 / 02期

关键词：

Nod样受体蛋白3; 炎症小体; 白细胞介素1β; 消化系统疾病;

D O I：

10.13764/j.cnki.ncdm.2018.02.021

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Nod样受体蛋白3(NLRP3)炎性小体是固有免疫系统的重要组成部分,其通过与下游的效应蛋白组装形成炎性小体而发挥作用,白细胞介素-1β(IL-1β)是其发挥作用的主要细胞因子。NLRP3炎性小体能被多种病原微生物以及内源性分子激活,从而使得组织中IL-1β的表达上调,其介导的炎性反应在消化系统疾病的发生发展中发挥着一定的作用。文章就NLRP3炎症小体的活化机制及其与消化系统疾病的关系作一综述。

引用

页码：87 / 91

页数：5

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