CRISPR结构与功能研究进展

被引：9

作者：

杨超杰

邱少富

宋宏彬

机构：

[1] 军事医学科学院疾病预防控制所

来源：

军事医学 | 2013年 / 02期

关键词：

规律成簇间隔短回文重复序列; 作用机制; 结构; 功能;

D O I：

暂无

中图分类号：

R341 []; Q933 [微生物遗传学];

学科分类号：

071007 ;

摘要：

研究发现,在细菌纲和古细菌纲中发现的规律成簇间隔短回文重复序列(clustered regularly interspacedshort palindromic repeat,CRISPR)构建了一种特殊的防御系统,能够有效地抵抗噬菌体和外界各种基因元件对其造成的干扰。CRISPR因其在结构上的特殊性以及功能上的特异性正逐渐成为细菌研究领域的热点。本文综述了近年来有关CRISPR系统的作用机制、分类、结构与相关功能的研究进展。

引用

页码：155 / 158

页数：4

共 37 条

[1] 规律成簇的间隔短回文重复:结构,功能与应用 [J].

崔玉军 ;

李艳君 ;

颜焱锋 ;

杨瑞馥 .

微生物学报, 2008, (11) :1549-1555

[2] CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during In Vivo Bacterial Infection [J].

Bikard, David ;

Hatoum-Aslan, Asma ;

Mucida, Daniel ;

Marraffini, Luciano A. .

CELL HOST & MICROBE, 2012, 12 (02) :177-186

[3]

Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage[J] . Ruiying Wang,Gan Preamplume,Michael P. Terns,Rebecca M. Terns,Hong Li. &nbspStructure . 2011 (2)

[4] Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense [J].

Wiedenheft, Blake ;

Zhou, Kaihong ;

Jinek, Martin ;

Coyle, Scott M. ;

Ma, Wendy ;

Doudna, Jennifer A. .

STRUCTURE, 2009, 17 (06) :904-912

[5]

The CRISPR/Cas immune system is an operon regulated byLeuO,H-NS,and leucine-responsive regulatory protein in Salmo-nella enterica serovar typhi. Medina-Aparicio L,Rebollar-Flores J,Gallego-Hernández A,etal. Journal of Bacteriology . 2011

[6] CRISPR-based adaptive and heritable immunity in prokaryotes [J].

van der Oost, John ;

Jore, Matthijs M. ;

Westra, Edze R. ;

Lundgren, Magnus ;

Brouns, Stan J. J. .

TRENDS IN BIOCHEMICAL SCIENCES, 2009, 34 (08) :401-407

[7]

MicroRNAs: Target Recognition and Regulatory Functions[J] . David P. Bartel. &nbspCell . 2009 (2)

[8] Characterization of the endonuclease SSO2001 from Sulfolobus solfataricus P2 [J].

Han, Dong ;

Krauss, Gerhard .

FEBS LETTERS, 2009, 583 (04) :771-776

[9] Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements [J].

Mojica, FJM ;

Díez-Villaseñor, C ;

García-Martínez, J ;

Soria, E .

JOURNAL OF MOLECULAR EVOLUTION, 2005, 60 (02) :174-182

[10]

Structural basis for DNaseactivity of a conserved protein implicated in CRISPR-mediatedgenome defense. Wiedenheft B,Zhou K,Jinek M,et al. Structure . 2009

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