依达拉奉对脑梗死大鼠神经保护作用最佳治疗时间窗的探讨

被引：14

作者：

张楠楠 ^{[1
,2
]}

陈会生 ^{[2
]}

机构：

[1] 大连医科大学研究生院

[2] 沈阳军区总医院神经内科

来源：

解放军医药杂志 | 2016年 / 28卷 / 03期

关键词：

大鼠,Sprague-Dawley; 梗死,大脑中动脉; 依达拉奉; 神经保护药; 治疗时间窗;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100706 [药理学];

摘要：

目的采用大鼠大脑中动脉梗塞(MCAO)模型,探讨依达拉奉治疗急性脑梗死的最佳治疗时间窗。方法将MCAO模型大鼠随机分为A、B、C、D和E组(n=10)。A、B、C、D组分别于造模后0.5 h、1 h、1.5 h、2 h通过尾静脉给予3 mg/kg的依达拉奉,E组于造模后给予等量的生理盐水。于梗死后24 h进行神经功能缺损评分,并测量脑梗死体积。结果 A、B、C组神经功能缺损评分和脑梗死体积均低于E组(P<0.05,P<0.01),其中B组与E组比较差异更显著(P<0.01),B组低于A、C、D组(P<0.05,P<0.01),B组与D组比较差异更显著(P<0.01)。结论对大鼠MCAO模型,依达拉奉具有神经保护作用,且其神经保护作用有治疗时间窗。

引用

页码：18 / 21

页数：4

共 21 条

[1]

Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: review of the literature [J].

Ren, Yanxin ;

Wei, Bing ;

Song, Xirui ;

An, Nan ;

Zhou, Yiying ;

Jin, Xinxin ;

Zhang, Yuyang .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2015, 125 (08) :555-565

[2]

Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review [J].

Wu, Simiao ;

Sena, Emily ;

Egan, Kieren ;

Macleod, Malcolm ;

Mead, Gillian .

INTERNATIONAL JOURNAL OF STROKE, 2014, 9 (01) :101-106

[3]

Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia [J].

Okamura, Koichi ;

Tsubokawa, Tamiji ;

Johshita, Hiroo ;

Miyazaki, Hiroshi ;

Shiokawa, Yoshiaki .

NEUROLOGICAL RESEARCH, 2014, 36 (01) :65-69

[4]

Therapeutic Time Window for Edaravone Treatment of Traumatic Brain Injury in Mice.[J].Kazuyuki Miyamoto;Hirokazu Ohtaki;Kenji Dohi;Tomomi Tsumuraya;Dandan Song;Keisuke Kiriyama;Kazue Satoh;Ai Shimizu;Tohru Aruga;Seiji Shioda;Norma Possa Marroni.BioMed Research International.2013,

[5]

Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat [J].

Ajmal Ahmad ;

Mohd. Moshahid Khan ;

Hayate Javed ;

Syed Shadab Raza ;

Tauheed Ishrat ;

M. Badruzzaman Khan ;

Mohammed M. Safhi ;

Fakhrul Islam .

Molecular and Cellular Biochemistry, 2012, 367 :215-225

[6]

Edaravone; a free radical scavenger; attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils.[J].Feng Lu;Takehiro Nakamura;Tetsuhiko Toyoshima;Yanan Liu;Kazuyuki Hirooka;Nobuyuki Kawai;Naohiko Okabe;Fumio Shiraga;Takashi Tamiya;Osamu Miyamoto;Richard F. Keep;Toshifumi Itano.Neuroscience Letters.2011, 1

[7]

The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress [J].