缺血修饰白蛋白与心肌缺血

被引:4
作者
张欣
何汝敏
曹久妹
机构
[1] 上海交通大学医学院附属瑞金医院心内科
关键词
急性冠脉综合征; 缺血修饰白蛋白; 心肌缺血; 诊断应用;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
急性冠脉综合征(ACS)具有发病急、变化快、临床表现与危险性不均一等特征,最好能在心肌细胞死亡之前对其做出诊断。目前常用的生化标志物均在心肌组织坏死后才释放入血液中,最近研究发现缺血修饰白蛋白(IMA)是较为理想的缺血标记物,具有极高的灵敏度,能在ACS早期可逆阶段检出,有助于ACS的除外诊断以及进行短期危险分层。本文对IMA在心肌缺血方面的应用做一综述。
引用
收藏
页码:236 / 239
页数:4
相关论文
共 8 条
[1]   Ischemia-modified albumin predicts mortality in ESRD [J].
Sharma, R ;
Gaze, DC ;
Pellerin, D ;
Mehta, RL ;
Gregson, H ;
Streather, CP ;
Collinson, PO ;
Brecker, SJD .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2006, 47 (03) :493-502
[2]   Comparison of ischemia-modified albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals [J].
Garrido, IP ;
Roy, D ;
Calviño, R ;
Vazquez-Rodriguez, JM ;
Aldama, G ;
Cosin-Sales, J ;
Quiles, J ;
Gaze, DC ;
Kaski, JC .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (01) :88-90
[3]  
Analytical performance of the Albumin Cobalt Binding (ACB?) test on the Cobas MIRA? Plus analyzer[J] . Stéphane Gidenne,Franck Ceppa,Eleonore Fontan,Fran?oise Perrier,Pascal Burnat.Clinical Chemistry and Laboratory Medicine . 2004 (4)
[4]   Relation of ischemia-modified albumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon-induced myocardial ischemia [J].
Quiles, J ;
Roy, D ;
Gaze, D ;
Garrido, IP ;
Avanzas, P ;
Sinha, M ;
Kaski, JC .
AMERICAN JOURNAL OF CARDIOLOGY, 2003, 92 (03) :322-324
[5]  
Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: A preliminary comparison to creatine kinase-MB, myoglobin, and troponin I[J] . David Bar-Or,James V. Winkler,Karyl VanBenthuysen,Lisbeth Harris,Edward Lau,Fred W. Hetzel.American Heart Journal . 2001 (6)
[6]  
Summary statistics for acute cardiac ischemia and chest pain visits to United States EDs, 1995–1996[J] . Catharine W Burt.American Journal of Emergency Medicine . 1999 (6)
[7]  
Reduction in the cobalt binding capacity of human albumin with myocardial ischemia[J] . D Bar-Or,E Lau,N Rao,N Bampos,JV Winkler,CG Curtis.Annals of Emergency Medicine . 1999 (4)
[8]  
Albumin cobalt binding assay to rule out acute cor-onary syndrome .2 ABADIEC J M,BLASSINGAME C L,BANKSON D D. Ann Clin Lab Sci . 2005