糖类药物

被引：9

作者：

杜晓光

耿美玉

机构：

[1] 中国科学院上海药物研究所

来源：

生命科学 | 2011年 / 23卷 / 07期

关键词：

糖类药物; 生物活性; 肿瘤; 老年痴呆; 抗病毒; 免疫调节;

D O I：

10.13376/j.cbls/2011.07.002

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

糖链作为重要的生物信息分子和高密度的信息载体,参与细胞生物几乎所有的生命过程,特别是在细胞分化、发育、免疫、老化、癌变、信息传递等生命基础活动和重大疾病过程中起着特异性的识别、介导与调控作用。由于糖类物质的多种多样的生物活性,糖类药物在抗肿瘤、老年痴呆、免疫、抗病毒等多个重大疾病领域广泛应用,而且其使用范围还在不断开拓中。因此,糖类药物生物活性多样,毒副作用低,具有广阔的发展前景。

引用

页码：671 / 677

页数：7

共 22 条

[11]

Neuroprotective Effects of Polysaccharides from Wolfberry, the Fruits of Lycium barbarum, Against Homocysteine-induced Toxicity in Rat Cortical Neurons[J] . Yuen-Shan Ho,Man-Shan Yu,Xi-Fei Yang,Kwok-Fai So,Wai-Hung Yuen,Raymond Chuen-Chung Chang.Journal of Alzheimer’s Disease . 2010 (3)

[12] Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum [J].

Guo, Liang ;

Xie, Jianhui ;

Ruan, Yuanyuan ;

Zhou, Lei ;

Zhu, Haiyan ;

Yun, Xiaojing ;

Jiang, Yan ;

Lue, Long ;

Chen, Kangli ;

Min, Zhihui ;

Wen, Yumei ;

Gu, Jianxin .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (10) :1175-1182

[13]

Heparanase and gallbladder cancer: New insights into understanding tumor growth and invasion[J] . UshaDutta,Kuchhangi SPoornachandra.Journal of Gastroenterology and Hepatology . 2008 (3)

[14] O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis [J].

Borgenstrom, Marjut ;

Warri, Anni ;

Hiilesvuo, Katri ;

Kakonen, Rami ;

Kakonen, Sanna ;

Nissinen, Liisa ;

Pihlavisto, Marjo ;

Marjamaki, Anne ;

Vlodavsky, Israel ;

Naggi, Annamaria ;

Torri, Giangiacomo ;

Casu, Benito ;

Verornaa, Tirno ;

Salmivirta, Markku ;

Elenius, Klaus .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2007, 33 (05) :547-556

[15]

Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, inhibits HIV-1 Tat-induced angiogenesis in Kaposi's sarcoma cells[J] . Cong-Xiao Lu,Jing Li,Yong-Xu Sun,Xin Qi,Qing-Juan Wang,Xian-Liang Xin,Mei-Yu Geng.Biochemical Pharmacology . 2007 (9)

[16] Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-β oligomers [J].

Townsend, Matthew ;

Cleary, James P. ;

Mehta, Tapan ;

Hofmeister, Jacki ;

Lesne, Sylvain ;

O'Hare, Eugene ;

Walsh, Dominic M. ;

Selkoe, Dennis J. .

ANNALS OF NEUROLOGY, 2006, 60 (06) :668-676

[17]

Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies[J] . Ralph D.Sanderson,YangYang,ThomasKelly,VeronicaMacLeod,YuemengDai,AllisonTheus.J. Cell. Biochem. . 2005 (5)

[18] Heparan sulfate proteoglycans and heparanase - partners in osteolytic tumor growth and metastasis [J].

Sanderson, RD ;

Yang, Y ;

Suva, LJ ;

Kelly, T .

MATRIX BIOLOGY, 2004, 23 (06) :341-352

[19] A novel early chorioallantoic membrane assay demonstrates quantitative and qualitative changes caused by antiangiogenic substances [J].

Hazel, SJ .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2003, 141 (03) :217-228

[20]

The potential molecular targets of marine sulfated polymannuroguluronate interfering with HIV-1 entry[J] . Geng Meiyu,Li Fuchuan,Xin Xianliang,Li Jing,Yan Zuowei,Guan Huashi.Antiviral Research . 2003 (2)

← 1 2 3 →