生物标志物在糖尿病肾病临床研究中的进展

被引：10

作者：

宋盼爱

詹明

Yashpal S.Kanwar

刘伏友

孙林

机构：

[1] 中南大学肾脏病研究所湖南省血液净化与肾脏病重点实验室湘雅二医院肾内科

来源：

中华肾脏病杂志 | 2012年 / 02期

关键词：

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症]; R692.9 [其他疾病];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

<正>糖尿病肾病(DN)是引起终末期肾脏疾病(ESRD)最常见的原因,约占ESRD患者的40%～50%。然而,DN发病机制尚未完全清楚,临床治疗措施有限,目前就DN的诊断而言,传统的肾活检由于具有一定的创伤性,限制了其临床应用,而尿白蛋白的检测又存在特异性不高的缺陷。因此,筛选早期、更准确的DN生物标志物不仅有助于更好地阐明DN的发生机制,且对DN的早期诊断、治疗效果的检测及预后的判断均具有重大意义。

引用

共 13 条

[1]

Clinical Significance of Urinary Liver-Type Fatty Acid-Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients [J].

Kamijo-Ikemori, Atsuko ;

Sugaya, Takeshi ;

Yasuda, Takashi ;

Kawata, Takehiro ;

Ota, Akio ;

Tatsunami, Shinobu ;

Kaise, Ruriko ;

Ishimitsu, Toshihiko ;

Tanaka, Yasushi ;

Kimura, Kenjiro .

DIABETES CARE, 2011, 34 (03) :691-696

[2]

A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy.[J].Yashpal S. Kanwar;Lin Sun;Ping Xie;Fu-you Liu;Sheldon Chen.Annual Review of Pathology: Mechanisms of Disease.2011, 1

[3]

Urinary Pigment Epithelium-Derived Factor as a Marker of Diabetic Nephropathy [J].

Chen, Haibing ;

Zheng, Zhi ;

Li, Rongxia ;

Lu, Junxi ;

Bao, Yuqian ;

Ying, Xiafang ;

Zeng, Rong ;

Jia, Weiping .

AMERICAN JOURNAL OF NEPHROLOGY, 2010, 32 (01) :47-56

[4]

The Use of Targeted Biomarkers for Chronic Kidney Disease [J].

Devarajan, Prasad .

ADVANCES IN CHRONIC KIDNEY DISEASE, 2010, 17 (06) :469-479

[5]

Urinary L-FABP and anaemia: distinct roles of urinary markers in type 2 diabetes [J].

von Eynatten, M. ;

Baumann, M. ;

Heemann, U. ;

Zdunek, D. ;

Hess, G. ;

Nawroth, P. P. ;

Bierhaus, A. ;

Humpert, P. M. .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2010, 40 (02) :95-102

[6]

Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy [J].

Cvetkovic, Tatjana ;

Mitic, Branka ;

Lazarevic, Gordana ;

Vlahovic, Predrag ;

Antic, Slobodan ;

Stefanovic, Vladisav .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2009, 23 (05) :337-342

[7]

Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy [J].

Tam, Frederick W. K. ;

Riser, Bruce L. ;

Meeran, Karim ;

Rambow, JoAnn ;

Pusey, Charles D. ;

Frankel, Andrew H. .

CYTOKINE, 2009, 47 (01) :37-42

[8]

Changes of serum and urine neutrophil gelatinase-associated lipocalin in type-2 diabetic patients with nephropathy: one year observational follow-up study [J].

Yang, Yi-Hua ;

He, Xiao-Jie ;

Chen, Shen-Ren ;

Wang, Ling ;

Li, En-Min ;

Xu, Li-Yan .

ENDOCRINE, 2009, 36 (01) :45-51

[9]

YKL-40, a Marker of Inflammation and Endothelial Dysfunction, Is Elevated in Patients With Type 1 Diabetes and Increases With Levels of Albuminuria [J].

Rathcke, Camilla Noelle ;

Persson, Frederik ;

Tarnow, Lise ;

Rossing, Peter ;

Vestergaard, Henrik .

DIABETES CARE, 2009, 32 (02) :323-328

[10]

Neutrophil gelatinase‐associated lipocalin (NGAL): A new marker of kidney disease.[J].Peasad Devarajan.Scandinavian Journal of Clinical & Laboratory Investigation.2008, S241

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