鼻腔给药系统的鼻粘膜毒性及解决途径

被引:78
作者
张奕
蒋新国
机构
[1] 复旦大学药学院药剂学教研室!上海,复旦大学药学院药剂学教研室!上海
关键词
鼻腔给药; 鼻纤毛毒性; 吸收促进剂;
D O I
暂无
中图分类号
R452 [投药法、用药法];
学科分类号
100231 [临床病理学];
摘要
就鼻腔给药系统可能导致的鼻粘膜毒性的评价方法、易产生毒性的制剂组分及解决毒性的方法进行简要的综述
引用
收藏
页数:5
相关论文
共 8 条
[1]
普萘洛尔鼻用制剂的纤毛毒性 [J].
蒋新国 ;
张奇志 ;
张奕 ;
奚念朱 .
药学学报, 1999, (06)
[2]
药物的鼻粘膜纤毛毒性及评价方法 [J].
蒋新国 ;
崔景斌 ;
方晓玲 ;
韦阳 ;
奚念朱 .
药学学报, 1995, (11)
[3]
Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats: Effects of absorption enhancers [J].
Marttin, E ;
Verhoef, JC ;
Cullander, C ;
Romeijn, SG ;
Nagelkerke, JF ;
Merkus, FWHM .
PHARMACEUTICAL RESEARCH, 1997, 14 (05) :631-637
[4]
Acute histopathological effects of benzalkonium chloride and absorption enhancers on rat nasal epithelium in vivo.[J].E. Marttin;J.C. Verhoef;S.G. Romeijn;P. Zwart;F.W.H.M. Merkus.International Journal of Pharmaceutics.1996, 1
[5]
Toxicological aspects of the use of dextran microspheres and thermogelling ethyl(hydroxyethyl) cellulose (EHEC) as nasal drug delivery systems.[J].Lena Pereswetoff-Morath;Sivert Bjurstrom;Rauf Khan;Maria Dahlin;Peter Edman.International Journal of Pharmaceutics.1996, 1
[6]
Effects of some preservative agents on rat and guinea pig tracheal and human nasal ciliary beat frequency [J].
Joki, S ;
Saano, V ;
Nuutinen, J ;
Virta, P ;
Karttunen, P ;
Silvasti, M ;
Toskala, E .
AMERICAN JOURNAL OF RHINOLOGY, 1996, 10 (03) :181-186
[7]
EFFECTS OF ABSORPTION ENHANCERS ON RAT NASAL EPITHELIUM IN-VIVO - RELEASE OF MARKER COMPOUNDS IN THE NASAL CAVITY [J].
MARTTIN, E ;
VERHOEF, JC ;
ROMEIJN, SG ;
MERKUS, FWHM .
PHARMACEUTICAL RESEARCH, 1995, 12 (08) :1151-1157
[8]
Methylated β-cyclodextrins are able to improve the nasal absorption of salmon calcitonin.[J].N. G. M. Schipper;J. C. Verhoef;S. G. Romeijn;F. W. H. M. Merkus.Calcified Tissue International.1995, 4