骨软骨连接处血管生成调控骨关节炎软骨潮线漂移的机制探讨

被引：4

作者：

李西海 ^{[1
]}

梁文娜 ^{[2
]}

叶蕻芝 ^{[1
]}

刘献祥 ^{[1
]}

机构：

[1] 福建中医药大学中西医结合研究院

[2] 福建中医药大学中医证研究基地

来源：

风湿病与关节炎 | 2014年 / 3卷 / 12期

关键词：

骨关节炎; 血管生成; 骨软骨连接; 关节软骨; 软骨细胞; 学术探讨;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨软骨连接处血管生成可反映软骨退变的程度,由促血管生成因子与抗血管生成因子的失衡所致,在骨关节炎的软骨潮线漂移、软骨基质矿化、软骨下骨重建及骨赘生成的病理过程中发挥重要的作用。骨软骨连接处血管生成,在于血管突破软骨钙化层与潮线改变了关节软骨独立于软骨下骨的微环境,而软骨下骨成骨细胞产生的调节因子,通过新生血管进入表层软骨而影响软骨细胞;软骨细胞也可分泌多种促血管生成因子,从而诱导血管侵入。基于国内外相关文献,探讨骨软骨连接处血管生成的结构、代谢改变与骨关节炎软骨潮线漂移的关系,旨在为治疗骨关节炎提供新的作用靶点。

引用

页码：51 / 54+71 +71

页数：5

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