头发、血浆皮质醇水平变化与抑郁症的相关性研究

被引：24

作者：

崔利军 ^{[1
]}

崔伟 ^{[1
]}

马小红 ^{[2
]}

于雪竹 ^{[1
]}

高景娜 ^{[1
]}

贾海玲 ^{[1
]}

郑冬瑞 ^{[1
]}

李媛媛 ^{[1
]}

赵连生 ^{[2
]}

栗克清 ^{[1
]}

机构：

[1] 河北省精神卫生中心

[2] 四川大学华西医院

来源：

中国神经精神疾病杂志 | 2017年 / 43卷 / 01期

关键词：

抑郁症; 头发皮质醇; 血浆皮质醇; 抗抑郁药; 相关性研究;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

目的探讨头发、血浆皮质醇水平在抑郁症发病过程中的特点及抗抑郁治疗前后的变化。方法纳入抑郁症患者47例和正常对照47名。抑郁症组给予选择性5-羟色胺再摄取抑制剂治疗4周,分别于治疗前、治疗4周后检测头发、血浆皮质醇水平,分别采用汉密尔顿抑郁量表17项(Hamilton Depression Rating Scale-17,HAMD-17)和汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评估抑郁症状和焦虑症状的严重程度及疗效。对照组不予干预,于入组时检测头发、血浆皮质醇水平。结果抑郁症组治疗前头发皮质醇水平高于对照组[(17.42±12.40)nmol/L vs.(10.22±8.00)nmol/L,P<0.01],血浆皮质醇水平两组间无统计学差异(P>0.05)。抑郁症组治疗后HAMD-17总分[(10.60±4.57)vs.(24.00±4.86)]和HAMA总分[(6.30±4.86)vs.(15.78±5.45)]较治疗前均降低(P<0.01),治疗后头发皮质醇水平较治疗前增高[(30.53±25.75)nmol/L vs.(16.02±11.77)nmol/L,P<0.05],血浆皮质醇水平治疗前后差异无统计学意义(P>0.05)。治疗后达到临床痊愈的患者治疗前血浆皮质醇水平高于非临床痊愈的患者[(27.47±14.48)nmol/L vs.(18.30±7.11)nmol/L,P<0.05]。抑郁症组治疗前血浆皮质醇水平与HAMD-17中的胃肠道症状因子分呈正相关(r=0.335,P=0.023),与HAMD-17总分及其他因子的相关性均无统计学意义(P>0.05)。结论抑郁症患者头发皮质醇水平高于正常对照,经抗抑郁药治疗后头发皮质醇水平较治疗前升高。治疗前血浆皮质醇水平高的患者可能对抗抑郁药治疗更敏感,可获得更好的临床疗效。

引用

页码：43 / 47

页数：5

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