重症监护病房机械通气患者不同镇静药物心血管不良事件观察

被引：4

作者：

杨明全

刘扬

周洁

机构：

[1] 自贡市第一人民医院重症医学科

来源：

华西医学 | 2018年 / 33卷 / 08期

关键词：

机械通气; 右美托咪定; 咪达唑仑; 不良事件; 安全性;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

目的观察重症监护病房(intensive care unit,ICU)机械通气长时镇静患者使用右美托咪定与咪达唑仑镇静心血管不良事件发生情况,对其安全性进行评价。方法选择2014年1月—2015年12月入住ICU年龄≥18周岁的机械通气时间≥48 h的患者,将其随机分成右美托咪定镇静组(D组)和咪达唑仑镇静组(M组)。观察镇静期间心血管等不良事件发生情况。结果 D组144例,M组143例。D组以心率减慢为突出表现,虽心率<50次/min需要异丙肾上腺素处理者(4.86%)较M组(6.29%)少,但差异无统计学意义(P=0.681)。D组血压下降(40.28%)、心动过速(18.75%)、心律失常(16.67%)、28 d病死率(22.22%)均低于M组(72.73%、41.96%、34.97%、42.66%),差异均有统计学意义(P<0.01)。两组未见心搏骤停、窦性停搏、高血压、高血糖、低血糖等表现。结论机械通气患者右美托咪定长时镇静是安全的,心血管不良事件中除心率减慢为突出表现外,其他较咪达唑仑传统镇静明显减少,28 d病死率更低,机械通气时间无明显延长,住ICU天数稍延长。

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收藏

页码：994 / 998

页数：5

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