组蛋白去甲基化酶JMJD及其抑制剂的研究进展

被引：12

作者：

王海

冯涛涛

孙昊鹏

尤启冬

机构：

[1] 中国药科大学药物化学教研室

来源：

药学进展 | 2013年 / 37卷 / 11期

关键词：

组蛋白去甲基化酶; JMJD; JMJD抑制剂; 肿瘤;

D O I：

暂无

中图分类号：

R914 [药物化学]; Q55 [酶];

学科分类号：

070307 [化学生物学]; 100705 [微生物与生化药学];

摘要：

组蛋白去甲基化酶JMJD家族可通过催化去除组蛋白N末端赖氨酸残基上甲基,参与表观遗传调控,包括基因表达调控,并与某些疾病,特别是癌症密切相关。因此,该酶已成为令人关注的癌症治疗新靶点,其抑制剂也成为药物研究与开发的热点。综述JMJD与肿瘤的关联、JMJD的结构和催化机制及其抑制剂的研究进展。

引用

页码：565 / 573

页数：9

共 15 条

[1]

组蛋白去甲基化酶研究进展 [J].

徐龙勇 ;

陈德桂 .

生命科学, 2010, 22 (02) :109-114

[2]

Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition [J].

Kogure, Masaharu ;

Takawa, Masashi ;

Cho, Hyun-Soo ;

Toyokawa, Gouji ;

Hayashi, Kazuyuki ;

Tsunoda, Tatsuhiko ;

Kobayashi, Takaaki ;

Daigo, Yataro ;

Sugiyama, Masanori ;

Atomi, Yutaka ;

Nakamura, Yusuke ;

Hamamoto, Ryuji .

CANCER LETTERS, 2013, 336 (01) :76-84

[3]

The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia [J].

Park, Seong-Joon ;

Kim, Joong-Gook ;

Son, Tae Gen ;

Yi, Joo Mi ;

Kim, Nam Deuk ;

Yang, Kwangmo ;

Heo, Kyu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 434 (04) :722-727

[4]

KDM3B Is the H3K9 Demethylase Involved in Transcriptional Activation of lmo2 in Leukemia [J].

Kim, Ji-Young ;

Kim, Kee-Beom ;

Eom, Gwang Hyeon ;

Choe, Nakwon ;

Kee, Hae Jin ;

Son, Hye-Ju ;

Oh, Si-Taek ;

Kim, Dong-Wook ;

Pak, Jhang Ho ;

Baek, Hee Jo ;

Kook, Hoon ;

Hahn, Yoonsoo ;

Kook, Hyun ;

Chakravarti, Debabrata ;

Seo, Sang-Beom .

MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (14) :2917-2933

[5]

Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C) [J].

Leurs, Ulrike ;

Clausen, Rasmus P. ;

Kristensen, Jesper L. ;

Lohse, Brian .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (18) :5811-5813

[6]

An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases.[J].Anup K. Upadhyay;Dante Rotili;Ji Woong Han;Ruogu Hu;Yanqi Chang;Donatella Labella;Xing Zhang;Young-sup Yoon;Antonello Mai;Xiaodong Cheng.Journal of Molecular Biology.2011, 3

[7]

Identification of catechols as histone–lysine demethylase inhibitors.[J].Anders L. Nielsen;Line H. Kristensen;Karen B. Stephansen;Jan B.L. Kristensen;Charlotte Helgstrand;Michael Lees;Paul Cloos;Kristian Helin;Michael Gajhede;Lars Olsen.FEBS Letters.2012, 8

[8]

Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer.[J].Wenjuan Li;Li Zhao;Wen Zang;Zhifang Liu;Long Chen;Tiantian Liu;Dawei Xu;Jihui Jia.Biochemical and Biophysical Research Communications.2011, 3

[9]

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors [J].

Hamada, Shohei ;

Kim, Tae-Dong ;

Suzuki, Takayoshi ;

Itoh, Yukihiro ;

Tsumoto, Hiroki ;

Nakagawa, Hidehiko ;

Janknecht, Ralf ;

Miyata, Naoki .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (10) :2852-2855

[10]

PLU-1 Is an H3K4 Demethylase Involved in Transcriptional Repression and Breast Cancer Cell Proliferation.[J].Kenichi Yamane;Keisuke Tateishi;Robert J. Klose;Jia Fang;Laura A. Fabrizio;Hediye Erdjument-Bromage;Joyce Taylor-Papadimitriou;Paul Tempst;Yi Zhang.Molecular Cell.2007, 6

← 1 2 →