以肿瘤干细胞为靶的免疫治疗

被引：12

作者：

郭坤元 ^{[1
]}

姚开泰 ^{[2
]}

机构：

[1] 南方医科大学珠江医院

[2] 南方医科大学肿瘤研究所

来源：

中国肿瘤生物治疗杂志 | 2012年 / 19卷 / 04期

关键词：

肿瘤干细胞; 免疫治疗; 靶向治疗;

D O I：

暂无

中图分类号：

R730.51 [免疫疗法];

学科分类号：

100108 [医学免疫学];

摘要：

肿瘤干细胞(cancer stem cell,CSC)是肿瘤发生和转移的种子细胞,CSC具有自我更新、增殖和不完全分化的能力。CSC对化疗/放疗的抵抗以及免疫逃逸成为肿瘤复发的根源,要提高肿瘤治愈率必须彻底清除CSC。认识CSC的标记特征和"干性"调节关键分子才能有效和特异地攻击CSC。免疫治疗具有抗原识别的靶向性和时空效应性,是以CSC为靶的治疗的基础;以单克隆抗体和致敏的免疫细胞为主要治疗技术的免疫治疗清除CSC具有可实践性和挑战性。

引用

收藏

页码：343 / 347

页数：5

相关论文

共 13 条

[1]

Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[2]

Cytotoxic T Lymphocytes Efficiently Recognize Human Colon Cancer Stem-Like Cells [J].

Inoda, Satoko ;

Hirohashi, Yoshihiko ;

Torigoe, Toshihiko ;

Morita, Rena ;

Takahashi, Akari ;

Asanuma, Hiroko ;

Nakatsugawa, Munehide ;

Nishizawa, Satoshi ;

Tamura, Yasuaki ;

Tsuruma, Tetsuhiro ;

Terui, Takeshi ;

Kondo, Toru ;

Ishitani, Kunihiko ;

Hasegawa, Tadashi ;

Hirata, Koichi ;

Sato, Noriyuki .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (04) :1805-1813

[3]

The Cancer Stem Cell Hypothesis: Failures and Pitfalls [J].

Rahman, Maryam ;

Deleyrolle, Loic ;

Vedam-Mai, Vinata ;

Azari, Hassan ;

Abd-El-Barr, Muhammad ;

Reynolds, Brent A. .

NEUROSURGERY, 2011, 68 (02) :531-545

[4]

Immunity to stemness genes in human cancer.[J].Madhav V Dhodapkar.Current Opinion in Immunology.2010, 2

[5]

Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells [J].

Hirohashi, Yoshihiko ;

Torigoe, Toshihiko ;

Inoda, Satoko ;

Takahashi, Akari ;

Morita, Rena ;

Nishizawa, Satoshi ;

Tamura, Yasuaki ;

Suzuki, Hiromu ;

Toyota, Minoru ;

Sato, Noriyuki .

IMMUNOTHERAPY, 2010, 2 (02) :201-211

[6]

CTLA-4 blockade: therapeutic potential in cancer treatments.[J].Ahmad Tarhini.OncoTargets and Therapy.2010, defa

[7]

The therapeutic promise of the cancer stem cell concept [J].

Frank, Natasha Y. ;

Schatton, Tobias ;

Frank, Markus H. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (01) :41-50

[8]

Antitumor Immunity and Cancer Stem Cells.[J].TobiasSchatton;Markus H.Frank.Annals of the New York Academy of Sciences.2009, 1

[9]

Antibodies targeting cancer stem cells A new paradigm in immunotherapy? [J].

Deonarain, Mahendra P. ;

Kousparou, Christina A. ;

Epenetos, Agamemnon A. .

MABS, 2009, 1 (01) :12-25

[10]

Stem-cell origin of metastasis and heterogeneity in solid tumours [J].

Tu, SM ;

Lin, SH ;

Logothetis, CJ .

LANCET ONCOLOGY, 2002, 3 (08) :508-513