VEGF在胃癌中的研究进展

被引：7

作者：

华宗荣 ^{[1
]}

李妍晨 ^{[1
]}

刘瑶 ^{[2
]}

黄才斌 ^{[2
]}

机构：

[1] 赣南医学院

[2] 赣南医学院第一附属医院消化内科

来源：

赣南医学院学报 | 2017年 / 37卷 / 01期

关键词：

血管内皮生长因子; 胃癌; 血管生成;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

胃癌是世界上最常见的癌症之一,胃癌的发生与发展必须依赖丰富的营养成分,在此过程中,肿瘤新生血管作为桥梁将营养成分提供给癌组织。如果癌组织的血管无法生成,那么依赖于养分的癌细胞将无法生长和转移。因此,血管生成是恶性肿瘤快速生长与远处转移的必要条件,研究肿瘤的血管生成对于抗肿瘤有着重要的意义。目前研究发现促进肿瘤血管生成的诱导因子包括血管内皮生长因子(Vascular endothelial growth factor,VEGF)、促血管生成素、环氧合酶-2、内皮抑素、一氧化氮等,其中VEGF能特异地促进内皮细胞的分裂、生存、增殖、侵袭和迁移,在肿瘤血管生成过程中起着至关重要的作用。

引用

页码：154 / 157

页数：4

共 16 条

[1]

Broad targeting of angiogenesis for cancer prevention and therapy.[J].Zongwei Wang;Charlotta Dabrosin;Xin Yin;Mark M. Fuster;Alexandra Arreola;W. Kimryn Rathmell;Daniele Generali;Ganji P. Nagaraju;Bassel El-Rayes;Domenico Ribatti;Yi Charlie Chen;Kanya Honoki;Hiromasa Fujii;Alexandros G. Georgakilas;Somaira Nowsheen;Amedeo Amedei;Elena Niccolai;Amr Amin;S. Salman Ashraf;Bill Helferich;Xujuan Yang;Gunjan Guha;Dipita Bhakta;Maria Rosa Ciriolo;Katia Aquilano;Sophie Chen;Dorota Halicka;Sulma I. Moham

[2]

Expression of VEGF-C/-D and lymphangiogenesis in salivary adenoid cystic carcinoma [J].

Starek, Ivo ;

Salzman, Richard ;

Kicerova, Ladislava ;

Skalova, Alena ;

Hauer, Lukas .

PATHOLOGY RESEARCH AND PRACTICE, 2015, 211 (10) :759-765

[3]

The JAK/STAT signaling cascade in gastric carcinoma (Review).[J].Puja Khanna;Pei Chua;Boon Bay;Gyeong Baeg.International Journal of Oncology.2015, 5

[4]

Global Cancer Statistics, 2012 [J].

Torre, Lindsey A. ;

Bray, Freddie ;

Siegel, Rebecca L. ;

Ferlay, Jacques ;

Lortet-Tieulent, Joannie ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2015, 65 (02) :87-108

[5]

High expressions of galectin-1 and VEGF are associated with poor prognosis in gastric cancer patients [J].

Chen, Jie ;

Tang, Dong ;

Wang, Sen ;

Li, Qing-Guo ;

Zhang, Ji-Ran ;

Li, Ping ;

Lu, Qi ;

Niu, Gang ;

Gao, Jun ;

Ye, Nian-Yuan ;

Wang, Dao-Rong .

TUMOR BIOLOGY, 2014, 35 (03) :2513-2519

[6]

Critical Appraisal of Ramucirumab (IMC-1121B) for Cancer Treatment: From Benchside to Clinical Use [J].

Aprile, Giuseppe ;

Bonotto, Marta ;

Ongaro, Elena ;

Pozzo, Carmelo ;

Giuliani, Francesco .

DRUGS, 2013, 73 (18) :2003-2015

[7]

VEGF is a target molecule for peritoneal metastasis and malignant ascites in gastric cancer: prognostic significance of VEGF in ascites and efficacy of anti-VEGF monoclonal antibody.[J].Sachio Fushida;Hidehiro Tajima;Kouichi Okamoto;Yasumichi Yagi;Jun Kinoshita;Katsunobu Oyama;Tetsuo Ohta;Takashi Fujimura;Itasu Ninomiya.OncoTargets and Therapy.2013, defa

[8]

Role of the VEGF/VEGFR Axis in Cancer Biology and Therapy.[J].Annamaria Rapisarda;Giovanni Melillo.Advances in Cancer Research.2012,

[9]

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis [J].