Basic and Therapeutic Aspects of Angiogenesis

被引:2299
作者
Potente, Michael [3 ,4 ]
Gerhardt, Holger [5 ,6 ]
Carmeliet, Peter [1 ,2 ]
机构
[1] Katholieke Univ Leuven, Lab Angiogenesis & Neurovasc Link, Vesalius Res Ctr, B-3000 Louvain, Belgium
[2] VIB, Lab Angiogenesis & Neurovasc Link, Vesalius Res Ctr, B-3000 Louvain, Belgium
[3] Goethe Univ Frankfurt, Vasc Epigenet Grp, Inst Cardiovasc Regenerat, Ctr Mol Med, D-60590 Frankfurt, Germany
[4] Goethe Univ Frankfurt, Dept Cardiol, D-60590 Frankfurt, Germany
[5] Canc Res UK, Vasc Biol Lab, London Res Inst, London WC2A 3LY, England
[6] VIB, Vasc Patterning Lab, Vesalius Res Ctr, B-3000 Louvain, Belgium
关键词
VASCULAR MORPHOGENESIS; EXTRACELLULAR-MATRIX; MOLECULAR-MECHANISMS; TUMOR VASCULATURE; ENDOTHELIAL NOTCH; METASTASIS; CANCER; GROWTH; PERICYTES; NORMALIZATION;
D O I
10.1016/j.cell.2011.08.039
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
引用
收藏
页码:873 / 887
页数:15
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