NF-κB在细胞凋亡中调节作用的研究进展

被引：80

作者：

任改艳 ^{[1
]}

孙阿宁 ^{[1
,2
]}

张晶晶 ^{[1
]}

邓超 ^{[1
]}

王峥涛 ^{[1
,2
]}

窦薇 ^{[1
]}

机构：

[1] 上海中医药大学中药研究所中药标准化教育部重点实验室暨上海市复方中药重点实验室

[2] 中国药科大学生药学研究室

来源：

中国药理学与毒理学杂志 | 2015年 / 29卷 / 02期

基金：

上海市自然科学基金;

关键词：

NF-κB; 细胞凋亡;

D O I：

暂无

中图分类号：

Q255 [细胞的衰老与死亡];

学科分类号：

071003 [生理学];

摘要：

细胞凋亡是由基因控制的细胞自主有序的主动死亡过程,主要有3条通路参与引起细胞凋亡,即细胞内的线粒体通路、内质网通路和细胞外的死亡受体通路。近年研究表明,NF-κB与细胞凋亡关系密切,具有抑制凋亡和促进凋亡的双向调节作用,其在细胞凋亡中调节作用与凋亡抑制蛋白家族、B细胞淋巴瘤/白血病-2家族、肿瘤坏死因子受体相关因子家族、c-Jun氨基端激酶、肿瘤坏死因子相关凋亡诱导配体和Fas相关死亡域蛋白样白细胞介素1β转化酶抑制蛋白等有关。探索NF-κB在细胞凋亡中的调控机制,对凋亡相关疾病的药物开发具有重要意义。本文就NF-κB在细胞凋亡中的调节作用进行综述。

引用

页码：323 / 327

页数：5

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