hs-CRP、D-二聚体和Lp-PLA2与冠心病患者冠状动脉粥样硬化易损斑块的相关性

被引：35

作者：

庄德荣 ^{[1
]}

何胜虎 ^{[2
]}

蔡定华 ^{[1
]}

王文苑 ^{[1
]}

田龙 ^{[1
]}

机构：

[1] 江苏省扬州市江都人民医院心血管内科

[2] 江苏省苏北人民医院(扬州大学医学院附属医院)心脏科

来源：

现代生物医学进展 | 2017年 / 17卷 / 26期

关键词：

超敏C反应蛋白; D-二聚体; 脂蛋白相关磷脂酶; 冠心病;

D O I：

10.13241/j.cnki.pmb.2017.26.029

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

目的:研究超敏C反应蛋白（hs-CRP）、D-二聚体和脂蛋白相关磷脂酶A2（Lp-PLA2）与冠心病患者冠状动脉粥样硬化易损斑块的相关性。方法:选择2014年1月2016年12月在我院进行冠状动脉造影和血管内超声检查的患者106例,按照检查结果分为易损斑块组、稳定斑块组和对照组。检测和比较三组患者的血清hs-CRP、D-二聚体和Lp-PLA2水平,并采用Pearson相关分析探讨其与纤维帽厚度、斑块偏心指数和血管重构指数的相关性。结果:易损斑块组和稳定斑块组的血清hs-CRP、D-二聚体和Lp-PLA2水平明显高于对照组（P<0.05）,且易损斑块组的血清hs-CRP、D-二聚体和Lp-PLA2水平明显高于稳定斑块组（P<0.05）。hs-CRP与纤维帽厚度呈负相关（r=-0.712,P<0.05）,与斑块偏心指数和血管重构指数呈正相关（r=0.813,0.756,P<0.05）;D-二聚体与纤维帽厚度呈负相关（r=-0.654,P<0.05）,与斑块偏心指数和血管重构指数呈正相关（r=0.912,0.853,P<0.05）;Lp-PLA2与纤维帽厚度呈负相关（r=-0.796,P<0.05）,与斑块偏心指数和血管重构指数呈正相关（r=0.836,0.729,P<0.05）。结论:hs-CRP、D-二聚体和Lp-PLA2与冠心病患者冠状动脉粥样硬化易损斑块具有较高的相关性,可作为评估冠状动脉粥样斑块不稳定性的参考指标。

引用

页码：5131 / 5133

页数：3

共 20 条

[1]

Perindopril and β-blocker for the prevention of cardiac events and mortality in stable coronary artery disease patients: A EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease (EUROPA) subanalysis [J].

Bertrand, Michel E. ;

Ferrari, Roberto ;

Remme, Willem J. ;

Simoons, Maarten L. ;

Fox, Kim M. .

AMERICAN HEART JOURNAL, 2015, 170 (06) :1092-1098

[2]

D-dimer for prediction of long-term outcome in cryptogenic stroke patients with patent foramen ovale [J].

Kim, Young Dae ;

Song, Dongbeom ;

Nam, Hyo Suk ;

Lee, Kijeong ;

Yoo, Joonsang ;

Hong, Geu-Ru ;

Lee, Hye Sun ;

Nam, Chung Mo ;

Heo, Ji Hoe .

THROMBOSIS AND HAEMOSTASIS, 2015, 114 (03) :614-622

[3]

LP-PLA2 LEVELS ARE INDEPENDANT OF STATIN TREATMENT IN DYSLIPIDEMIC PATIENTS [J].

Rosenbaum, D. ;

Mattina, A. ;

Bittar, R. ;

Bruckert, E. ;

Rousselot, D. Bonnefont ;

Giral, P. .

ATHEROSCLEROSIS, 2015, 241 (01) :E109-E109

[4]

Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women [J].

Kim, Mi Joung ;

Hwang, Jung Hyun ;

Ko, Hyun Ji ;

Na, Hye Bock ;

Kim, Jung Hee .

NUTRITION RESEARCH, 2015, 35 (05) :409-420

[5]

Positive remodeling index by MSCT coronary angiography: A prognostic factor for early detection of plaque rupture and vulnerability [J].

Abdeldayem, Emad H. ;

Ibrahim, Ahmed S. ;

Ahmed, Amr M. ;

Genedi, Eman S. ;

Tantawy, Wahid H. .

EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE, 2015, 46 (01) :13-24

[6]

D-dimer level predicts in-hospital mortality in patients with infective endocarditis: A prospective single-centre study [J].

Turak, Osman ;

Canpolat, Ugur ;

Ozcan, Firat ;

Yayla, Cagri ;

Mendi, Mehmet Ali ;

Oksuz, Fatih ;

Tok, Duran ;

Tok, Derya ;

Cagli, Kumral ;

Golbasi, Zehra .

THROMBOSIS RESEARCH, 2014, 134 (03) :587-592

[7]

Inflammation in Coronary Artery Disease [J].

Christodoulidis, Georgios ;

Vittorio, Timothy J. ;

Fudim, Marat ;

Lerakis, Stamatios ;

Kosmas, Constantine E. .

CARDIOLOGY IN REVIEW, 2014, 22 (06) :279-288

[8]

Prevalence of nonalcoholic fatty liver disease (NAFLD) in patients of cardiovascular diseases and its association with hs-CRP and TNF-α.[J].Masihur Rehman Ajmal;Monika Yaccha;Mohammed Azharuddin Malik;M.U. Rabbani;Ibne Ahmad;Najmul Isalm;Nasar Abdali.Indian Heart Journal.2014,

[9]

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D [J].