熊果酸和齐墩果酸抗皮肤癌与白血病药理作用的研究进展

被引：55

作者：

张明发

沈雅琴

机构：

[1] 上海美优制药有限公司

来源：

抗感染药学 | 2012年 / 9卷 / 03期

关键词：

熊果酸; 齐墩果酸; 皮肤癌; 白血病; 药理作用;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

熊果酸和齐墩果酸是化学立体结构相同的同分异构体,广泛存在于各种植物之中,具有广泛的生物活性(如保肝、抗炎、抗微生物、抗糖尿病和抗肿瘤)等作用。综述熊果酸和齐墩果酸抑制皮肤乳头瘤的形成、抗黑色素瘤、淋巴系和髓系白血病等药理作用及其机制的研究进展。

引用

页码：177 / 181

页数：5

共 44 条

[1]

Sensitization of ionizing radiation-induced apoptosis by ursolic acid [J].

Koh, Su Jin ;

Tak, Jean Kyoung ;

Kim, Seon Tae ;

Nam, Woo Suk ;

Kim, Sung Youl ;

Park, Kwon Moo ;

Park, Jeen-Woo .

FREE RADICAL RESEARCH, 2012, 46 (03) :339-345

[2]

Ursolic Acid-induced Apoptosis in K562 Cells Involving Upregulation of PTEN Gene Expression and Inactivation of the PI3K/Akt Pathway [J].

Wu, Bin ;

Wang, Xu ;

Chi, Zuo-fei ;

Hu, Rong ;

Zhang, Rong ;

Yang, Wei ;

Liu, Zhuo-gang .

ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (03) :543-548

[3]

A novel form of melanoma apoptosis resistance: Melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death [J].

Pinon, Aline ;

Limami, Youness ;

Micallef, Ludovic ;

Cook-Moreau, Jeanne ;

Liagre, Bertrand ;

Delage, Christiane ;

Duval, Raphael Emmanuel ;

Simon, Alain .

EXPERIMENTAL CELL RESEARCH, 2011, 317 (12) :1669-1676

[4]

Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPβ expression by ERK pathway activation [J].

Zhang, Ting ;

He, Yun-Mian ;

Wang, Jin-Song ;

Shen, Jing ;

Xing, Ying-Ying ;

Xi, Tao .

ANTI-CANCER DRUGS, 2011, 22 (02) :158-165

[5]

Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells [J].

Manu, K. A. ;

Kuttan, Girija .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2008, 8 (07) :974-981

[6]

Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines [J].

Bonaccorsi, Irene ;

Altieri, Fabio ;

Sciamanna, Ilaria ;

Oricchio, Elisa ;

Grillo, Caterina ;

Contartese, Giuseppe ;

Galati, Enza Maria .

CANCER LETTERS, 2008, 263 (01) :130-139

[7]

Differential involvement of mitochondria during ursolic acid-induced apoptotic process in HaCaT and M4Beu cells [J].

Duval, Raphael Emmanuel ;

Harmand, Pierre-Olivier ;

Jayat-Vignoles, Chantal ;

Cook-Moreau, Jeanne ;

Pinon, Aline ;

Delage, Christiane ;

Simon, Alain .

ONCOLOGY REPORTS, 2008, 19 (01) :145-149

[8]

Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in Balb/c mice [J].

Resende, Flavia Aparecida ;

Mattos de Andrade Barcala, Claudete Aparecida ;

da Silva Faria, Mdrcia Cristina ;

Kato, Fabiana Hibary ;

Cunha, Wilson Roberto ;

Tavares, Denise Crispim .

LIFE SCIENCES, 2006, 79 (13) :1268-1273

[9]

Dual activity of triterpenoids: apoptotic versus antidifferentiation effects [J].

Cipak, Lubos ;

Grausova, Lubica ;

Miadokova, Eva ;

Novotny, Ladislav ;

Rauko, Peter .

ARCHIVES OF TOXICOLOGY, 2006, 80 (07) :429-435

[10]

Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects [J].

Banno, N ;

Akihisa, T ;

Tokuda, H ;

Yasukawa, K ;

Higashihara, H ;

Ukiya, M ;

Watanabe, K ;

Kimura, Y ;

Hasegawa, J ;

Nishino, H .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2004, 68 (01) :85-90

← 1 2 3 4 5 →