Ursolic Acid-induced Apoptosis in K562 Cells Involving Upregulation of PTEN Gene Expression and Inactivation of the PI3K/Akt Pathway

被引：69

作者：

Wu, Bin ^{[1
]}

Wang, Xu ^{[2
]}

Chi, Zuo-fei ^{[1
]}

Hu, Rong ^{[1
]}

Zhang, Rong ^{[1
]}

Yang, Wei ^{[1
]}

Liu, Zhuo-gang ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Hematol, Shenyang, Peoples R China

[2] China Med Univ, Hosp 1, Endoscopy Ctr, Shenyang, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2012年 / 35卷 / 03期

关键词：

Ursolic acid; PTEN; K562; Apoptosis; MYELOID-LEUKEMIA CELLS; SIGNALING PATHWAY; CANCER CELLS; ACTIVATION; SURVIVAL; DEPHOSPHORYLATES; INDUCTION; KINASE;

D O I：

10.1007/s12272-012-0318-1

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Ursolic acid (UA), a pentacyclic triterpenoid derived from a variety of medicinal plants, exhibits potent anticancer activity against many types of cancer cells. However, the anticancer mechanism of UA is not clearly understood. Suppression of phosphatase and a tensin homolog deleted on chromosome 10 (PTEN) gene expression leading to activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway has been observed in many cancers including leukemia, making the PTEN gene and PI3K/Akt pathway a central target for cancer therapy. Here, we demonstrated that UA was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (K562 cells) via upregulation of PTEN gene expression, inhibit Akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases. These results suggest that UA may elicit its strong antitumor effects via upregulation of the PTEN gene and inhibition of the PI3K/Akt pathway.

引用

页码：543 / 548

页数：6

共 21 条

[1]

The Akt/PKB pathway: molecular target for cancer drug discovery [J].