PI3K/AKT信号通路在肿瘤中的研究进展

被引：104

作者：

施银

冯晓兰

谢李芬

王筱冰

机构：

[1] 陕西师范大学生命科学学院

来源：

生命的化学 | 2018年 / 38卷 / 03期

关键词：

PI3K/AKT; 信号通路; 肿瘤;

D O I：

10.13488/j.smhx.20180312

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

恶性肿瘤的发生发展是多种信号传导通路共同作用的结果。在多种肿瘤发生过程中PI3K/AKT信号传导通路出现异常活化,该通路在肿瘤发生发展过程中起着关键作用,参与肿瘤细胞存活、增殖、侵袭与迁移的调控。抑制该通路的方案已成为肿瘤治疗的研究热点。文章对PI3K/AKT通路的组成、分子机制、功能以及与肿瘤的关系进行了综述。

引用

页码：421 / 426

页数：6

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