Bioactive constituents from the rhizomes of Atractylodes macrocephala

被引：13

作者：

Zhang, Haixin ^{[1
]}

Lin, Chunyu ^{[1
]}

Yin, Luying ^{[1
]}

Si, Jinguang ^{[1
]}

Yu, Meng ^{[1
]}

Li, Jingrong ^{[1
,3
]}

Li, Lingyu ^{[1
]}

Zhang, Tao ^{[1
,2
]}

Zou, Zhongmei ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[3] Guizhou Med Univ, Med Sci, Guiyang 550000, Peoples R China

来源：

FITOTERAPIA | 2023年 / 165卷

基金：

中国国家自然科学基金;

关键词：

Compositae; Atractylodes macrocephala Koidz; Sesquiterpene; Norneolignan; SESQUITERPENOIDS; IRIDOIDS;

D O I：

10.1016/j.fitote.2023.105431

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Twelve undescribed compounds including five sesquiterpenes (1-5), one monoterpene (6), and four lignans (7a/ 7b and 8a/8b), along with two other types (9 and 10) were isolated from the rhizomes of Atractylodes macro-cephala. Among them, two pairs of enantiomers (7a/7b and 8a/8b) were successfully separated by chiral-phase HPLC, while racemate 9 could not be resolved. Their structures and absolute configurations were unambiguously elucidated by spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Notably, com-pounds 1 and 2 are rare sesquiterpene hybrids featuring an eudesmanolactam linked to a resorcinol or methyl 2-methylpentanoat through a C-N bond. Compound 3 represents the first example of eudesmanolide sesquiter-pene with an oxygen-bridge between C-8 and C-14. Compounds 7a and 7b are a pair of rare enantiomeric benzodioxane norneolignans. Additionally, compound 2 exhibited weak cytotoxicity against SGC-7901 cells. Compound 4 significantly promoted the proliferation of LPS-induced IEC-6 cells with the rate of 117.2%.

引用

页数：11

共 25 条

[1]

Inhibition of the Akt/NF-κB pathway is involved in the anti-gastritis effects of an ethanolic extract of the rhizome of Atractylodes macrocephala [J].