Atractylodes macrocephala Rhizomes Contain Anti-inflammatory Sesquiterpenes

被引：2

作者：

Hai, Cao Thanh ^{[1
,2
,3
]}

Luyen, Nguyen Thi ^{[2
]}

Giang, Do Hoang ^{[2
]}

Minh, Bui Quang ^{[2
]}

Trung, Nguyen Quang ^{[2
]}

Chinh, Pham The ^{[3
]}

Hau, Dang Viet ^{[1
,2
]}

Dat, Nguyen Tien ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi 122100, Vietnam

[2] VAST, Ctr Res & Technol Transfer, 18 Hoang Quoc Viet, Hanoi 122100, Vietnam

[3] Thai Nguyen Univ Sci, Tan Thinh Ward, Thai Nguyen 251580, Vietnam

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2023年 / 71卷 / 06期

关键词：

Atractylodes macrocephala; eudesmane; secoatractylolactone; anti-inflammation; atractylenolide III; ESSENTIAL OILS; JAPONICA;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two new compounds, named eudesm-4(15),7-diene-3 alpha,9 beta,11-triol (1) and eudesm-4(15),7-diene-1 beta, 3 alpha,9 beta,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-beta-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using one-dimensional (1D) and 2D-NMR spectra and high resolution electrospray ionization (HR-ESI)-MS data. Compound 5 exhibited the most active anti-inflammatory activity with IC50 values of 27.5 mu M in inhibiting of nitric oxide production. Compounds 1, 2, and 3 showed moderate effects while compound 4 was inactive.

引用

页码：451 / 453

页数：3

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