共 62 条
EGFR assays in lung cancer
被引:40
作者:

Dacic, Sanja
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA
机构:
[1] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA
关键词:
lung cancer;
EGFR;
mutational analysis;
FISH;
D O I:
10.1097/PAP.0b013e31817bf5a9
中图分类号:
R36 [病理学];
学科分类号:
100104 ;
摘要:
The development of small-molecule inhibitors of the epidermal growth factor receptor (EGFR) resulted in new therapeutic options for patients with advanced lung cancer. It was clear from the experience with targeted therapy for breast cancer that a new standardized assay procedure for assessing and predicting the effects of therapeutic agents must be developed. Three academic groups almost simultaneously reported the discovery of somatic mutations in the exons 18 to 21 of the tyrosine kinase (TK) domain of EGFR that correlated with a high likelihood of response to EGFR TK inhibitors. This observation revolutionized understanding of EGFR in lung carcinogenesis and resulted in numerous retrospective studies that correlated patient's response and molecular profile of the lung adenocarcinoma. The results of these studies indicate that clinical benefits from treatment with EGFR TK inhibitors are variable between the different subsets of patients. Multiple methodologic approaches were used including mutational analysis, fluorescence in situ hybridization, and immunohistochemistry. Conflicting results reflect the lack of standardization of the methodology and interpretation. Sample types, sample processing, and storage should also be taken into consideration as another potentially confounding factor. Therefore, it is important to standardize the approach and decide which assays are best to predict patient response to targeted therapies. It is also essential to determine the most cost-effective way to integrate EGFR molecular assays into clinical practice. This review will address practical aspects of each of the currently proposed assays. Difficulties in standardization of these assays in a clinical practice will be discussed.
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页码:241 / 247
页数:7
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共 62 条
[41]
EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy
[J].
Paez, JG
;
Jänne, PA
;
Lee, JC
;
Tracy, S
;
Greulich, H
;
Gabriel, S
;
Herman, P
;
Kaye, FJ
;
Lindeman, N
;
Boggon, TJ
;
Naoki, K
;
Sasaki, H
;
Fujii, Y
;
Eck, MJ
;
Sellers, WR
;
Johnson, BE
;
Meyerson, M
.
SCIENCE,
2004, 304 (5676)
:1497-1500

Paez, JG
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Jänne, PA
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Lee, JC
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Tracy, S
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Greulich, H
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Gabriel, S
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Herman, P
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Kaye, FJ
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Lindeman, N
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Boggon, TJ
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Naoki, K
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Sasaki, H
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Fujii, Y
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Eck, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Sellers, WR
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Johnson, BE
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

Meyerson, M
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[42]
Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
[J].
Pan, QL
;
Pao, W
;
Ladanyi, M
.
JOURNAL OF MOLECULAR DIAGNOSTICS,
2005, 7 (03)
:396-403

Pan, QL
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

Pao, W
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

Ladanyi, M
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
[43]
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
[J].
Pao, W
;
Miller, V
;
Zakowski, M
;
Doherty, J
;
Politi, K
;
Sarkaria, I
;
Singh, B
;
Heelan, R
;
Rusch, V
;
Fulton, L
;
Mardis, E
;
Kupfer, D
;
Wilson, R
;
Kris, M
;
Varmus, H
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2004, 101 (36)
:13306-13311

Pao, W
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Miller, V
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Zakowski, M
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Doherty, J
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Politi, K
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Sarkaria, I
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Singh, B
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Heelan, R
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Rusch, V
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Fulton, L
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Mardis, E
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Kupfer, D
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Wilson, R
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Kris, M
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

Varmus, H
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA
[44]
Epidermal growth factor receptor mutation testing in lung cancer: Searching for the ideal method
[J].
Pao, William
;
Laclanyi, Marc
.
CLINICAL CANCER RESEARCH,
2007, 13 (17)
:4954-4955

Pao, William
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA

Laclanyi, Marc
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
[45]
Epidermal growth factor receptor (EGFR) gene copy number detection in non-small-cell lung cancer;: a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization
[J].
Ruiz, M. I. Gallegos
;
Floor, K.
;
Vos, W.
;
Grunberg, K.
;
Meijer, G. A.
;
Rodriguez, J. A.
;
Giaccone, G.
.
HISTOPATHOLOGY,
2007, 51 (05)
:631-637

Ruiz, M. I. Gallegos
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

Floor, K.
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

Vos, W.
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

Grunberg, K.
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

Meijer, G. A.
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

Rodriguez, J. A.
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

论文数: 引用数:
h-index:
机构:
[46]
Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer
[J].
Sasaki, Hidefumi
;
Endo, Katsuhiko
;
Okuda, Katsuhiro
;
Kawano, Osamu
;
Kitahara, Naoto
;
Tanaka, Hisaichi
;
Matsumura, Akihide
;
Iuchi, Keiji
;
Takada, Minoru
;
Kawahara, Masaaki
;
Kawaguchi, Tomoya
;
Yukiue, Haruhiro
;
Yokoyama, Tomoki
;
Yano, Motoki
;
Fujii, Yoshitaka
.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,
2008, 134 (05)
:569-577

Sasaki, Hidefumi
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Endo, Katsuhiko
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Okuda, Katsuhiro
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Kawano, Osamu
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Kitahara, Naoto
论文数: 0 引用数: 0
h-index: 0
机构:
Kinki Chuo Chest Med Ctr, Dept Surg, Sakai, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Tanaka, Hisaichi
论文数: 0 引用数: 0
h-index: 0
机构:
Kinki Chuo Chest Med Ctr, Dept Surg, Sakai, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Matsumura, Akihide
论文数: 0 引用数: 0
h-index: 0
机构:
Kinki Chuo Chest Med Ctr, Dept Surg, Sakai, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Iuchi, Keiji
论文数: 0 引用数: 0
h-index: 0
机构:
Kinki Chuo Chest Med Ctr, Dept Surg, Sakai, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Takada, Minoru
论文数: 0 引用数: 0
h-index: 0
机构:
Kinki Chuo Chest Med Ctr, Dept Internal Med, Sakai, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Kawahara, Masaaki
论文数: 0 引用数: 0
h-index: 0
机构:
Kinki Chuo Chest Med Ctr, Dept Internal Med, Sakai, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Kawaguchi, Tomoya
论文数: 0 引用数: 0
h-index: 0
机构:
Kinki Chuo Chest Med Ctr, Dept Internal Med, Sakai, Osaka, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Yukiue, Haruhiro
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Yokoyama, Tomoki
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Yano, Motoki
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

Fujii, Yoshitaka
论文数: 0 引用数: 0
h-index: 0
机构:
Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan
[47]
Epidermal growth factor receptor mutation testing in the care of lung cancer patients
[J].
Sequist, Lecia V.
;
Joshi, Victoria A.
;
Jaenne, Pasi A.
;
Bell, Daphne W.
;
Fidias, Pahos
;
Lindeman, Neal I.
;
Louis, David N.
;
Lee, Jeffrey C.
;
Mark, Eugene J.
;
Longtine, Janina
;
Verlander, Peter
;
Kucherlapati, Raju
;
Meyerson, Matthew
;
Haber, Daniel A.
;
Johnson, Bruce E.
;
Lynch, Thomas J.
.
CLINICAL CANCER RESEARCH,
2006, 12 (14)
:4403S-4408S

Sequist, Lecia V.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Joshi, Victoria A.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Jaenne, Pasi A.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Bell, Daphne W.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Fidias, Pahos
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Lindeman, Neal I.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Louis, David N.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Lee, Jeffrey C.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Mark, Eugene J.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Longtine, Janina
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Verlander, Peter
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Kucherlapati, Raju
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Meyerson, Matthew
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Haber, Daniel A.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Johnson, Bruce E.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA

Lynch, Thomas J.
论文数: 0 引用数: 0
h-index: 0
机构: Massachusetts Gen Hosp, Ctr Canc, Yawkey Ctr Outpatient Care, Boston, MA 02114 USA
[48]
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
[J].
Shigematsu, H
;
Gazdar, AF
.
INTERNATIONAL JOURNAL OF CANCER,
2006, 118 (02)
:257-262

Shigematsu, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA

Gazdar, AF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[49]
Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced nonsmall cell lung cancer
[J].
Shih, JY
;
Gow, CH
;
Yu, CJ
;
Yang, CH
;
Chang, YL
;
Tsai, MF
;
Hsu, YC
;
Chen, KY
;
Su, WP
;
Yang, PC
.
INTERNATIONAL JOURNAL OF CANCER,
2006, 118 (04)
:963-969

Shih, JY
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Gow, CH
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Yu, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Yang, CH
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Chang, YL
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Tsai, MF
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Hsu, YC
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Chen, KY
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Su, WP
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

Yang, PC
论文数: 0 引用数: 0
h-index: 0
机构: Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan
[50]
EGFR mutation conferring primary resistance to gefitinib in non-small-cell lung cancer
[J].
Shih, JY
;
Gow, CH
;
Yang, PC
.
NEW ENGLAND JOURNAL OF MEDICINE,
2005, 353 (02)
:207-208

Shih, JY
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Taipei 100, Taiwan Natl Taiwan Univ Hosp, Taipei 100, Taiwan

Gow, CH
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Taipei 100, Taiwan Natl Taiwan Univ Hosp, Taipei 100, Taiwan

Yang, PC
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Taipei 100, Taiwan Natl Taiwan Univ Hosp, Taipei 100, Taiwan