Electrostatic charging during a melt agglomeration process

被引:18
作者
Eliasen, H [1 ]
Kristensen, HG [1 ]
Schæfer, T [1 ]
机构
[1] Royal Danish Sch Pharm, Dept Pharmaceut, DK-2100 Copenhagen, Denmark
关键词
static electricity; air humidity; resistivity; adhesion; melt agglomeration; high shear mixer;
D O I
10.1016/S0378-5173(99)00102-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Lactose monohydrate was melt agglomerated in an 8-1 high shear mixer using stearic acid, polyethylene glycol (PEG) 3000, and a mixture of stearic acid and glycerol monostearate as meltable binders. Electrostatic charging during processing at relative air humidities of 35 and 75%, respectively, was estimated from the voltage of a monitoring probe inserted into the mixer. Stearic acid produced a high level of electrostatic charges, whereas PEG 3000 gave rise to a markedly lower level. Addition of glycerol monostearate to the stearic acid reduced the level of electrostatic charges. A correlation was found between the resistivity of the binder and the level of electrostatic charges in the material. With the stearic acid and the binder mixture, the level of electrostatic charges was higher at a low air humidity. The amount of adhesion to the bowl was found to depend on the level of electrostatic charges; (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:85 / 96
页数:12
相关论文
共 29 条
[11]  
Jonassen N., 1998, Electrostatics
[12]   Controlling static electricity in hazardous (classified) locations [J].
Kassebaum, JH ;
Kocken, RA .
IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, 1997, 33 (01) :209-215
[13]  
Mackin L.A., 1997, PHARM SCI, V3, P583
[14]   Influence of powder properties on the performance of electrostatic coating process [J].
Mazumder, MK ;
Wankum, DL ;
Sims, RA ;
Mountain, JR ;
Chen, H ;
Pettit, P ;
Chaser, T .
JOURNAL OF ELECTROSTATICS, 1997, 40-1 :369-374
[15]   THE ROLE OF WATER-VAPOR IN THE CHARGE ELIMINATION PROCESS FOR FLOWING POWDERS [J].
NGUYEN, T ;
NIEH, S .
JOURNAL OF ELECTROSTATICS, 1989, 22 (02) :213-227
[16]  
Pavey I, 1998, PHARM TECHNOL EUR, V10, P24
[17]  
PEERBOOM C, 1995, P 1 WORLD M PHARM BI, P361
[18]   MELT PELLETIZATION IN A HIGH-SHEAR MIXER .5. EFFECTS OF APPARATUS VARIABLES [J].
SCHAEFER, T ;
TAAGEGAARD, B ;
THOMSEN, LJ ;
KRISTENSEN, HG .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 1 (03) :133-141
[19]   Melt pelletization in a high shear mixer .6. Agglomeration of a cohesive powder [J].
Schaefer, T .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 132 (1-2) :221-230
[20]   Melt pelletization in a high shear mixer .7. Effects of product temperature [J].
Schaefer, T ;
Mathiesen, C .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 134 (1-2) :105-117