COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression

被引：325

作者：

Krogan, NJ

Dover, J

Khorrami, S

Greenblatt, JF

Schneider, J

Johnston, M

Shilatifard, A

机构：

[1] St Louis Univ, Sch Med, Dept Biochem, St Louis, MO 63104 USA

[2] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[3] Univ Toronto, Banting & Best Dept Med Res, Dept Mol & Med Genet, Toronto, ON M5G 1L6, Canada

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2002年 / 277卷 / 13期

关键词：

D O I：

10.1074/jbc.C200023200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The trithorax (Trx) family of proteins is required for maintaining a specific pattern of gene expression in some organisms. Recently we reported the isolation and characterization of COMPASS, a multiprotein complex that includes the Trx-related protein Set1of the yeast Saccharomyces cerevisiae. Here we report that COMPASS catalyzes methylation of the fourth lysine of histone H3 in vitro. Setl and several other components of COMPASS are also required for histone H3 methylation in vivo and for transcriptional silencing of a gene located near a chromosome telomere.

引用

页码：10753 / 10755

页数：3

共 29 条

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