Histone H3 phosphorylation and cell division

被引：402

作者：

Hans, F ^{[1
]}

Dimitrov, S ^{[1
]}

机构：

[1] Inst Albert Bonniot, Equipe Mecanismes Assemblage Mat Genet, Lab Biol Mol & Cellulaire Differenciat, INSERM,U309, F-38706 La Tronche, France

来源：

ONCOGENE | 2001年 / 20卷 / 24期

关键词：

histone H3; phosphorylation; mitosis; meiosis;

D O I：

10.1038/sj.onc.1204326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone H3 is specifically phosphorylated during both mitosis and meiosis in patterns that are specifically coordinated in both space and time. Histone H3 phosphorylation may initiate at different phases of the cell division in different organisms, but metaphase chromosomes are always found to be heavily phosphorylated. Upon exit of mitosis/meiosis a global dephosphorylation of H3 takes place. Potential candidates for H3 kinases are described and their hypothetical mechanism of action on highly condensed chromatin templates is discussed. In addition, a novel hypothesis for the role of histone HS phosphorylation during cell division is proposed. This hypothesis, termed the 'ready production label' model, explains the results in the literature and suggests that phosphorylation of histone H3 is a part of a complex signaling mechanism.

引用

页码：3021 / 3027

页数：7

共 65 条

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