9-(4-Dimethylaminophenyl)benzo[b]quinolizinium: A Near-Infrared Fluorophore for the Multicolor Analysis of Proteins and Nucleic Acids in Living Cells

被引:52
作者
Bortolozzi, Roberta [1 ]
Ihmels, Heiko [2 ]
Thomas, Laura [2 ]
Tian, Maoqun [2 ]
Viola, Giampietro [1 ]
机构
[1] Univ Padua, Dipartimento Salute Donna & Bambino, Lab Oncoematol, I-35128 Padua, Italy
[2] Univ Siegen, Dept Chem Biol, D-57068 Siegen, Germany
关键词
DNA; emission spectroscopy; fluorescent probes; imaging agents; EXCITED-STATE RELAXATION; FLUORESCENCE LIGHT-UP; DNA-BINDING; CHARGE-TRANSFER; ACRIDIZINIUM SALTS; CIRCULAR-DICHROISM; HIGH-SENSITIVITY; THIOFLAVIN-T; COMPLEXES; PROBES;
D O I
10.1002/chem.201301164
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
All lit up: The title compound operates as a fluorescent light-up probe that enables the detection of different biologically relevant hosts at different fluorescence maxima. It is demonstrated that this chemosensor also allows the fluorimetric multicolor analysis of different components in living cells (see figure). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:8736 / 8741
页数:6
相关论文
共 86 条
[81]   Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(II) complex with four-stranded DNA structures [J].
Wilson, Tom ;
Williamson, Mike P. ;
Thomas, Jim A. .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (11) :2617-2621
[82]   Simultaneous fluorescence light-up and selective multicolor nucleobase recognition based on sequence-dependent strong binding of berberine to DNA abasic site [J].
Wu, Fei ;
Shao, Yong ;
Ma, Kun ;
Cui, Qinghua ;
Liu, Guiying ;
Xu, Shujuan .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (16) :3300-3307
[83]   A Molecular Peptide Beacon for the Ratiometric Sensing of Nucleic Acids [J].
Wu, Junchen ;
Zou, Ying ;
Li, Chunyan ;
Sicking, Wilhelm ;
Piantanida, Ivo ;
Yi, Tao ;
Schmuck, Carsten .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (04) :1958-1961
[84]   Two-Photon Fluorescent Probes for Bioimaging [J].
Yao, Sheng ;
Belfield, Kevin D. .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (17) :3199-3217
[85]   Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging [J].
Yuan, Lin ;
Lin, Weiying ;
Zheng, Kaibo ;
He, Longwei ;
Huang, Weimin .
CHEMICAL SOCIETY REVIEWS, 2013, 42 (02) :622-661
[86]   Highly selective, naked-eye and fluorescent "off-on" probe for detection of histidine/histidine-rich proteins and its application in living cell imaging [J].
Zhang, Shenyi ;
Yang, Chunmei ;
Zhu, Weiping ;
Zeng, Bubing ;
Yang, Youjun ;
Xu, Yufang ;
Qian, Xuhong .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (08) :1653-1658