Chemical and photochemical ligation of oligonucleotide blocks

被引：15

作者：

Letsinger, RL

Wu, TF

Elghanian, R

机构：

[1] Department of Chemistry, Northwestern University, Evanston

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 5-6期

关键词：

D O I：

10.1080/07328319708002929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide containing a -OP(O)(O-)S- link can function as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.

引用

收藏

页码：643 / 652

页数：10

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