A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [123I]CNS 1261

被引：17

作者：

Bressan, RA

Erlandsson, K ^{[1
]}

Mulligan, RS

Gunn, RN

Cunningham, VJ

Owens, J

Cullum, ID

Ell, PJ

Pilowsky, LS

机构：

[1] UCL Med Sch, Inst Nucl Med, London, England

[2] Inst Psychiat, London SE5 8AF, England

[3] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[4] Hammersmith Hosp, IRSL, London W12 0NN, England

[5] Univ Glasgow, Western Infirm, W Scotland Radionucl Dispensary, Glasgow G11 6NT, Lanark, Scotland

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2004年 / 31卷 / 02期

基金：

英国医学研究理事会;

关键词：

NMDA receptors; dynamic SPET; kinetic modeling; constant infusion; equilibrium analysis; volume of distribution;

D O I：

10.1016/j.nucmedbio.2003.08.008

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We have previously performed quantitative kinetic modeling of [I-123] CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 healthy volunteers. Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [I-123]CNS 1261 in clinical populations. (C) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：155 / 164

页数：10

相关论文

共 22 条

[11] Spatial registration and normalization of images [J].

Friston, KJ ;

Ashburner, J ;

Frith, CD ;

Poline, JB ;

Heather, JD ;

Frackowiak, RSJ .

HUMAN BRAIN MAPPING, 1995, 3 (03) :165-189

[12] CENTRAL-NERVOUS-SYSTEM EFFECTS OF SUBDISSOCIATIVE DOSES OF (S)-KETAMINE ARE RELATED TO PLASMA AND BRAIN CONCENTRATIONS MEASURED WITH POSITRON EMISSION TOMOGRAPHY IN HEALTHY-VOLUNTEERS [J].

HARTVIG, P ;

VALTYSSON, J ;

LINDNER, KJ ;

KRISTENSEN, J ;

KARLSTEN, R ;

GUSTAFSSON, LL ;

PERSSON, J ;

SVENSSON, JO ;

OYE, I ;

ANTONI, G ;

WESTERBERG, G ;

LANGSTROM, B .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 58 (02) :165-173

[13] TRADITIONAL RECEPTOR THEORY AND ITS APPLICATION TO NEURORECEPTOR MEASUREMENTS IN FUNCTIONAL IMAGING [J].

KERWIN, RW ;

PILOWSKY, LS .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1995, 22 (07) :699-710

[14] GLOBALLY CONVERGENT ALGORITHMS FOR MAXIMUM A-POSTERIORI TRANSMISSION TOMOGRAPHY [J].

LANGE, K ;

FESSLER, JA .

IEEE TRANSACTIONS ON IMAGE PROCESSING, 1995, 4 (10) :1430-1438

[15] Imaging synaptic neurotransmission with in vivo binding competition techniques:: A critical review [J].

Laruelle, M .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (03) :423-451

[16] SPECT QUANTIFICATION OF [I-123] IOMAZENIL BINDING TO BENZODIAZEPINE RECEPTORS IN NONHUMAN-PRIMATES .1. KINETIC MODELING OF SINGLE BOLUS EXPERIMENTS [J].

LARUELLE, M ;

BALDWIN, RM ;

RATTNER, Z ;

ALTIKRITI, MS ;

ZEAPONCE, Y ;

ZOGHBI, SS ;

CHARNEY, DS ;

PRICE, JC ;

FROST, JJ ;

HOFFER, PB ;

INNIS, RB .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1994, 14 (03) :439-452

[17]

LAURELLE M, 1994, J CEREB BLOOD FLOW M, V14, P453

[18] A QUANTITATIVE MODEL FOR THE INVIVO ASSESSMENT OF DRUG-BINDING SITES WITH POSITRON EMISSION TOMOGRAPHY [J].

MINTUN, MA ;

RAICHLE, ME ;

KILBOURN, MR ;

WOOTEN, GF ;

WELCH, MJ .

ANNALS OF NEUROLOGY, 1984, 15 (03) :217-227

[19]

Mulligan R. S., 2001, Journal of Labelled Compounds and Radiopharmaceuticals, V44, pS228

[20] A PRACTICAL METHOD FOR POSITION-DEPENDENT COMPTON-SCATTER CORRECTION IN SINGLE PHOTON-EMISSION CT [J].

OGAWA, K ;

HARATA, Y ;

ICHIHARA, T ;

KUBO, A ;

HASHIMOTO, S .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 1991, 10 (03) :408-412