Bacterial genomics and pathogen evolution

被引：98

作者：

Raskin, DM

Seshadri, R

Pukatzki, SU

Mekalanosl, JJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

[2] Inst Gen Res, Rockville, MD 20850 USA

来源：

CELL | 2006年 / 124卷 / 04期

关键词：

D O I：

10.1016/j.cell.2006.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results. Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date.

引用

页码：703 / 714

页数：12

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