Kinetic resolution in asymmetric anti aldol reactions of branched and straight chain racemic 2-phenylsulfanyl aldehydes: Asymmetric synthesis of cyclic ethers and lactones by phenylsulfanyl migration

被引：10

作者：

Chibale, K ^{[1
]}

Warren, S ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CHEM LABS,CAMBRIDGE CB2 1EW,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 16期

关键词：

D O I：

10.1039/p19960001935

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The kinetic resolution of branched and straight chain 2-phenylsulfanyl aldehydes by the Lewis acid-catalysed asymmetric anti aldol reaction followed by reduction to single enantiomers of 1,3-diols and/or acid-catalysed cyclisation with PhS migration provides a route to enantiomerically pure cyclic ethers and lactones with full stereochemical control.

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收藏

页码：1935 / 1940

页数：6

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