New antihepatotoxic cerebroside from Lycium chinense fruits

被引：105

作者：

Kim, SY

Choi, YH

Huh, H

Kim, J

Kim, YC

Lee, HS

机构：

[1] SEOUL NATL UNIV,COLL PHARM,SEOUL 151742,SOUTH KOREA

[2] SEOUL NATL POLYTECH UNIV,DEPT FOOD SCI & TECHNOL,SEOUL 139743,SOUTH KOREA

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 03期

关键词：

D O I：

10.1021/np960670b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two cerebrosides isolated from Lycium chinense fruits have been characterized as 1-O-beta-D-glucopyranosyl-(2S,3R,4E,8Z)-2-N-palmitoyloctadecasphinga-4,8-dienine (1) and 1-O-beta-D-glucopyranosyl-(2S,3R,4E,8Z)-2-N-(2'-hydroxypalmitoyl)octadecasphinga-4,8-dienine (2). While 2 is already known, the structure of 1 was determined by spectral and chemical studies. Incubation of CCl4-intoxicated hepatocytes with 1 and 2, respectively, significantly reduced the levels of glutamic pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) released by injured cells.

引用

页码：274 / 276

页数：3

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