Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones

被引：57

作者：

Baalwa, Joshua ^{[1
]}

Wang, Shuyi ^{[3
]}

Parrish, Nicholas F. ^{[3
]}

Decker, Julie M. ^{[4
]}

Keele, Brandon F. ^{[5
]}

Learn, Gerald H. ^{[3
]}

Yue, Ling ^{[6
]}

Ruzagira, Eugene ^{[7
]}

Ssemwanga, Deogratius ^{[7
]}

Kamali, Anatoli ^{[7
]}

Amornkul, Pauli N. ^{[8
]}

Price, Matt A. ^{[8
]}

Kappes, John C. ^{[4
]}

Karita, Etienne ^{[6
]}

Kaleebu, Pontiano ^{[7
]}

Sanders, Eduard ^{[8
]}

Gilmour, Jill ^{[8
]}

Allen, Susan ^{[9
]}

Hunter, Eric ^{[6
]}

Montefiori, David C. ^{[10
]}

Haynes, Barton F. ^{[10
]}

Cormier, Emmanuel ^{[8
]}

Hahn, Beatrice H. ^{[3
]}

Shaw, George M. ^{[2
,3
]}

机构：

[1] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[2] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA

[4] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[5] SAIC Frederick Inc, AIDS & Canc Virus Program, Frederick Natl Lab Canc Res, Ft Detrick, MD 21702 USA

[6] Emory Univ, Dept Pathol, Atlanta, GA 30322 USA

[7] Uganda Virus Res Inst, Med Res Council Program AIDS, Entebbe, Uganda

[8] Int AIDS Vaccine Initiat, New York, NY 10004 USA

[9] Emory Univ, Dept Global Hlth, Atlanta, GA 30322 USA

[10] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA

来源：

VIROLOGY | 2013年 / 436卷 / 01期

关键词：

HIV-1; Transmitted/founder virus; Single genome sequencing; transmission; HIV-1 subtype A; HIV-1 subtype D; Neutralizing antibodies; HUMAN-IMMUNODEFICIENCY-VIRUS; FASTER DISEASE PROGRESSION; GP41 CYTOPLASMIC TAIL; 2ND CODING EXON; TYPE-1; SUBTYPE; HETEROSEXUAL TRANSMISSION; NEUTRALIZING ANTIBODIES; GENOTYPIC CHARACTERISTICS; ENVELOPE GLYCOPROTEINS; CORECEPTOR TROPISM;

D O I：

10.1016/j.virol.2012.10.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the molecular identification, cloning and initial biological characterization of 12 full-length HIV-1 subtype A, D and AID recombinant transmitted/founder (T/F) genomes. T/F genomes contained intact canonical open reading frames and all TIP viruses were replication competent in primary human T-cells, although subtype D virus replication was more efficient (p <0.05). All 12 viruses utilized CCR5 but not CXCR4 as a co-receptor for entry and exhibited a neutralization profile typical of tier 2 primary virus strains, with significant differences observed between subtype A and D viruses with respect to sensitivity to monoclonal antibodies VRC01, PG9 and PG16 and polyclonal subtype C anti-HIV IgG (p <0.05 for each). The present report doubles the number of T/F HIV-1 clones available for pathogenesis and vaccine research and extends their representation to include subtypes A, B, C and D. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：33 / 48

页数：16

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