A novel class of conformationally restricted oligonucleotide analogues: Synthesis of 2',3'-bridged monomers and RNA-selective hybridisation

被引：37

作者：

Nielsen, P

Pfundheller, HM

Wengel, J

机构：

[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE M,DENMARK

[2] UNIV COPENHAGEN,DEPT CHEM,DK-2100 COPENHAGEN,DENMARK

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 09期

关键词：

D O I：

10.1039/a608231i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel 2',3'-bicyclic nucleoside 5 has been synthesised and incorporated into oligonucleotide analogues resulting in strong and selective binding to an RNA complement.

引用

页码：825 / 826

页数：2

共 20 条

[1] 1',6'-METHANO CARBOCYCLIC THYMIDINE - SYNTHESIS, X-RAY CRYSTAL-STRUCTURE, AND EFFECT ON NUCLEIC-ACID DUPLEX STABILITY
ALTMANN, KH
IMWINKELRIED, R
KESSELRING, R
RIHS, G
[J]. TETRAHEDRON LETTERS, 1994, 35 (41) : 7625 - 7628
[2] 4',6'-METHANO CARBOCYCLIC THYMIDINE - A CONFORMATIONALLY CONSTRAINED BUILDING-BLOCK FOR OLIGONUCLEOTIDES
ALTMANN, KH
KESSELRING, R
FRANCOTTE, E
RIHS, G
[J]. TETRAHEDRON LETTERS, 1994, 35 (15) : 2331 - 2334
[3] CHEMICAL SYNTHESIS OF DNA AND DNA ANALOGS
CARUTHERS, MH
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (09) : 278 - 284
[4] ANTISENSE OLIGONUCLEOTIDES
DEMESMAEKER, A
HANER, R
MARTIN, P
MOSER, HE
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1995, 28 (09) : 366 - 374
[5] CRYSTAL-STRUCTURE OF A PARALLEL-STRANDED DUPLEX OF A DEOXYCYTIDYLYL-(3'-5')-DEOXYCYTIDINE ANALOG CONTAINING INTRANUCLEOSIDYL C(3')-C(5') ETHYLENE BRIDGES
EGLI, M
LUBINI, P
BOLLI, M
DOBLER, M
LEUMANN, C
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (13) : 5855 - 5856
[6] NUCLEOSIDES .16. FURTHER STUDIES OF ANHYDRONUCLEOSIDES
FOX, JJ
MILLER, NC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1963, 28 (04) : 936 - &
[7] Herdewijn P, 1996, LIEBIGS ANN, P1337
[8] OLIGONUCLEOTIDES CONTAINING A COVALENT CONFORMATIONALLY RESTRICTED PHOSPHODIESTER ANALOG FOR HIGH-AFFINITY TRIPLE-HELIX FORMATION - THE RIBOACETAL INTERNUCLEOTIDE LINKAGE
JONES, RJ
SWAMINATHAN, S
MILLIGAN, JF
WADWANI, S
FROEHLER, BC
MATTEUCCI, MD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) : 9816 - 9817
[9] Nucleic-acid analogs with restricted conformational flexibility in the sugar-phosphate backbone ('Bicyclo-DNA') .6. Probing the influence of torsion angle gamma on DNA-duplex stability: Synthesis and properties of oligodeoxynucleotides containing [(3'S,5'S)-2'-deoxy-3','-ethano-beta-D-ribofuranosy]adenine and -thymine ('5'-epi-bicyclodeoxynucleosides')
Litten, JC
Leumann, C
[J]. HELVETICA CHIMICA ACTA, 1996, 79 (04) : 1129 - 1146
[10] Stereoselective synthesis of 3'-C-allyluridines and 3'-spiro-gamma-lactone uridine analogues
Nielsen, P
Larsen, K
Wengel, J
[J]. ACTA CHEMICA SCANDINAVICA, 1996, 50 (11): : 1030 - 1035

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