Oxidative Pd(II)-Catalyzed C-H Bond Amination to Carbazole at Ambient Temperature

被引：508

作者：

Jordan-Hore, James A. ^{[1
]}

Johansson, Carin C. C. ^{[1
]}

Gulias, Moises ^{[1
]}

Beck, Elizabeth M. ^{[1
]}

Gaunt, Matthew J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 48期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ja806543s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a new Pd(II)-catalyzed C-H bond amination reaction to form carbazoles, an important motif that is prevalent in a range of systems. The catalytic amination process operates under extremely mild conditions and produces carbazole products in good to excellent yields, Carbazoles possessing complex molecular architecture can also be formed using this reaction, highlighting its potential in natural product synthesis applications. Preliminary mechanistic investigations reveal the reaction proceeds through a Pd(II)/Pd(IV) manifold and that reductive elimination from a high oxidation state Pd(IV) complex facilitates the mild conditions of this transformation.

引用

页码：16184 / +

页数：4

共 51 条

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