Ferrocene-mediated proton-coupled electron transfer in a series of ferrocifen-type breast-cancer drug candidates

被引：393

作者：

Hillard, E

Vessières, A

Thouin, L

Jaouen, G

Amatore, C

机构：

[1] Ecole Normale Super, Lab Chim & Biochim Complexes Mol, F-75231 Paris 05, France

[2] Ecole Normale Super, Dept Chim, F-75231 Paris 05, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 02期

关键词：

antitumor agents; electrochemistry; electron transfer; hormones; metallocenes;

D O I：

10.1002/anie.200502925

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A double-barreled approach: The addition of ferrocene to an antiestrogen drug skeleton was found to induce cytotoxicity towards breast-cancer cells that are resistant to the common antiestrogen drug. The efficacy of this drug has been related to the proton-coupled electron transfer observed in the presence of pyridine as a base (see picture). (Chemical Equation Presented) © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：285 / 290

页数：6

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