Synthesis, resolution and determination of energy barriers to rotation of atropisomeric, planar-chiral [n]paracyclophanes by dynamic enantioselective gas chromatography and computer simulation

被引：37

作者：

Hochmuth, DH ^{[1
]}

König, WA ^{[1
]}

机构：

[1] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(99)00092-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We herein report on the synthesis of substituted carbocyclic [11]paracyclophanes, which are planar-chiral and atropisomeric. Their energy barrier to rotation was determined by dynamic enantioselective gas chromatography on selectively modified cyclodextrins as chiral stationary phases and subsequent computer simulation of the plateau-shaped elution profiles (DGC-CS). The energy barriers are compared with those of analogous dioxa[11]paracyclophanes. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1089 / 1097

页数：9

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