Copper-Promoted Sandmeyer Trifluoromethylation Reaction

被引：255

作者：

Dai, Jian-Jun ^{[1
]}

Fang, Chi ^{[1
]}

Xiao, Bin ^{[2
,3
]}

Yi, Jun ^{[1
]}

Xu, Jun ^{[1
]}

Liu, Zhao-Jing ^{[1
]}

Lu, Xi ^{[1
]}

Liu, Lei ^{[2
,3
]}

Fu, Yao ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[2] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 23期

基金：

中国博士后科学基金;

关键词：

PALLADIUM-CATALYZED TRIFLUOROMETHYLATION; METAL-FREE BORYLATION; OXIDATIVE TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; MEDICINAL CHEMISTRY; BORONIC ACIDS; ARYLBORONIC ACIDS; SULFONIUM SALTS; ARYL RADICALS; ARENES;

D O I：

10.1021/ja404217t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-promoted trifluoromethylation reaction of aromatic amines is described. This transformation proceeds smoothly under mild conditions and exhibits good tolerance of many synthetically relevant functional groups. It provides an alternative approach for the synthesis of trifluoromethylated arenes and heteroarenes. It also constitutes a new example of the Sandmeyer reaction.

引用

页码：8436 / 8439

页数：4

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