Characterizing dispersion in microfluidic channels

被引：52

作者：

Datta, Subhra ^{[1
]}

Ghosal, Sandip ^{[2
]}

机构：

[1] Ohio State Univ, Columbus, OH 43210 USA

[2] Northwestern Univ, Evanston, IL 60208 USA

来源：

LAB ON A CHIP | 2009年 / 9卷 / 17期

关键词：

CAPILLARY-ZONE-ELECTROPHORESIS; PERFORMANCE LIQUID-CHROMATOGRAPHY; FIELD-FLOW FRACTIONATION; ELECTROOSMOTIC FLOW; ELECTROKINETIC TRANSPORT; HYDRODYNAMIC DISPERSION; PRESSURE-DRIVEN; LAMINAR-FLOW; SEPARATION; SOLUTE;

D O I：

10.1039/b822948c

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Dispersion or spreading of analyte bands is a barrier to achieving high resolution in microfluidic separations. The role of dispersion in separations is reviewed with emphasis on metrics, sources and common principles of analysis. Three sources of dispersion (a) inhomogeneous flow fields, (b) solute wall interactions and (c) force fields normal to channel walls are studied in detail. Microfluidic and nanofluidic applications to capillary electrophoresis, chromatography and field-flow fractionation, that are subject to one or more of these three physical processes under standard, unintentional or novel operating conditions, are discussed.

引用

页码：2537 / 2550

页数：14

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